TY - JOUR AU - Topless, Ruth K. G. AU - Major, Tanya J. AU - Florez, Jose C. AU - Hirschhorn, Joel N. AU - Cadzow, Murray AU - Dalbeth, Nicola AU - Stamp, Lisa K. AU - Wilcox, Philip L. AU - Reynolds, Richard J. AU - Cole, Joanne B. AU - Merriman, Tony R. PY - 2021 DA - 2021/03/04 TI - The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: diet has a weak causal effect JO - Arthritis Research & Therapy SP - 75 VL - 23 IS - 1 AB - Prevention of hyperuricaemia (HU) is critical to the prevention of gout. Understanding causal relationships and relative contributions of various risk factors to hyperuricemia is therefore important in the prevention of gout. Here, we use attributable fraction to compare the relative contribution of genetic, dietary, urate-lowering therapy (ULT) and other exposures to HU. We use Mendelian randomisation to test for the causality of diet in urate levels. SN - 1478-6362 UR - https://doi.org/10.1186/s13075-021-02444-8 DO - 10.1186/s13075-021-02444-8 ID - Topless2021 ER -