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Table 2 Population attributable and average attributable fractions for HU risk exposures

From: The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: diet has a weak causal effect

 

Cohort 1 (US-based)

Cohort 2 (UK-based)

Cohort 3 (UK-based)

Gout cohort (UK-based)

OR (95% CI)

PAF (95% CI)

AAF (95% CI)

OR (95% CI)

PAF (95% CI)

AAF (95% CI)

OR (95% CI)

PAF (95% CI)

AAF (95% CI)

OR (95% CI)

PAF (95% CI)

AAF (95% CI)

Sex - male

6.2 (5.4; 7.0)

64.3 (64.6; 67.8)

29.8 (29.2; 30.3)

8.2 (7.5; 8.9)

75.6 (74.6; 76.5)

30.9 (30.2; 31.6)

7.5 (7.3; 7.8)

73.4 (73.0; 73.8)

30.8 (30.2; 31.5)

4.9 (3.7; 6.6)

76.7 (69.9; 81.7)

30.2 (29.7; 30.6)

BMI ≥25 kg/m2

3.4 (3.0; 3.8)

59.2 (55.8; 62.2)

23.5 (23.1; 24.0)

4.2 (3.8; 4.6)

68.6 (66.2; 70.8)

26.2 (25.5; 26.8)

3.8 (3.6; 3.9)

66.4 (65.4; 67.3)

25.8 (25.2; 26.4)

2.1 (1.6; 2.7)

48.8 (36.4; 58.4)

14.2 (14.0; 14.2)

SLC2A9, rs12498742

A-allele present

2.4 (1.8; 3.2)

56.6 (43.8; 66.3)

22.0 (21.6; 22.4)

2.9 (2.4; 3.5)

63.8 (56.2; 70.0)

23.5 (22.9; 0.24)

2.7 (2.5; 2.9)

61.7 (58.8; 64.3)

23.1 (22.6; 23.7)

1.9 (1.2; 3.2)

47.8 (16.2; 67.3)

13.5 (13.3; 13.8)

Diet non-adherence

1.3 (0.6; 2.4)#

20.3 (54.6; 58.8)#

6.3 (6.2; 6.5) #

1.3 (1.2; 1.5) #

23.6 (12.7; 33.0) #

7.1 (6.9; 7.3) #

1.3 (1.2; 1.4) *

21.4 (8.2; 24.4)*

6.5 (6.3; 6.7)*

1.2 (0.9; 1.4)*

11.8 (−7.3; 27.2)*

2.7 (2.6; 2.7)*

Alcohol ≥1 drink/week

1.1 (1.0; 1.2)

5.2 (−0.1; 10.0)

1.5 (1.4; 1.5)

1.3 (1.2; 1.4)

19.5 (14.2; 24.3)

5.7 (5.6; 5.9)

1.3 (1.3; 1.4)

19.4 (17.5; 21.2)

5.9 (5.7; 6.0)

1.1 (0.9; 1.4)

10.0 (−5.8; 23.1)

2.2 (2.2; 2.3)

On diuretic therapy

4.8 (4.2; 5.5)

21.1 (20.3; 21.9)

8.7 (8.6; 8.9)

4.2 (3.8; 4.6)

15.1 (14.6; 15.5)

4.8 (4.7; 5.0)

4.3 (4.2; 4.5)

17.1 (16.9; 17.3)

5.8 (5.6; 5.9)

1.7 (1.4; 2.0)

6.4 (4.6; 7.9)

1.8 (1.7; 1.8)

Age ≥ 50 years

1.3 (1.1; 1.4)

15.1 (8.7; 20.9)

4.7 (4.6; 4.8)

1.0 (0.9; 1.1)

0.4 (−6.4; 6.6)

0.1 (0.1; 0.1)

1.0 (1.0; 1.0)

0.2 (−2.4; 2.7)

0.1 (0.1; 0.1)

^

^

^

Not treated with urate-lowering therapy

^

^

^

^

^

^

^

^

^

21.8 (18.9; 25.1)

63.2 (62.7; 63.6)

33.3 (32.8; 33.7)

  1. #Non-adherence to DASH guidelines; *Non-adherence to the Harvard Healthy Eating Pyramid guidelines; ^Data not applicable or variable is not a risk factor in this group
  2. All analyses are adjusted in a multivariable model for the other risk factors. OR calculations were done in a logistic regression model. For the gout cohort in a model including age, the OR was 0.5 (0.4; 0.6). For SLC2A9 rs12498742, PAF and AAF were calculated under a dominant model for the A-allele
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Arthritis Research & Therapy

ISSN: 1478-6362

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