Table 3 Associations of dichotomised risk variables with serum urate levels (including percent variance explained)
Risk factor | Cohort 1 (US-based) | Cohort 2 (UK-based) | Cohort 3 (UK-based) | Gout cohort (UK-based) | ||||
|---|---|---|---|---|---|---|---|---|
Beta (95% CI) | R2 (%) | Beta (95% CI) | R2 (%) | Beta (95% CI) | R2 (%) | Beta (95% CI) | R2 (%) | |
Sex - male | 0.078 (0.076; 0.080) | 22.4 | 0.076 (0.075; 0.077) | 27.2 | 0.075 (0.075; 0.076) | 25.9 | 0.062 (0.055; 0.070) | 3.7 |
BMI ≥25 kg/m2 | 0.041 (0.038; 0.043) | 7.3 | 0.039 (0.038; 0.041) | 9.0 | 0.040 (0.039; 0.040) | 8.5 | 0.032 (0.025; 0.039) | 1.8 |
SLC2A9, rs12498742 A-allele present | 0.044 (0.039; 0.049) | 2.5 | 0.048 (0.046; 0.050) | 3.4 | 0.047 (0.046; 0.047) | 3.0 | 0.026 (0.009; 0.043) | 0.02 |
Diet non-adherence | 0.008 (−0.006; 0.021)# | 0.01 | 0.008 (0.006; 0.010)# | 0.1 | 0.005 (0.004; 0.005)* | 0.1 | 0.004 (−0.003; 0.010)* | 0.01 |
Alcohol ≥1 drink/week | 0.004 (0.002; 0.007) | 0.2 | 0.008 (0.007; 0.009) | 0.4 | 0.009 (0.008; 0.009) | 0.5 | 0.005 (−0.001; 0.010) | 0.3 |
On diuretic therapy | 0.058 (0.054; 0.061) | 11.7 | 0.047 (0.045; 0.049) | 3.7 | 0.049 (0.048; 0.050) | 4.5 | 0.029 (0.029; 0.035) | 1.7 |
Age ≥ 50 years | 0.014 (0.012; 0.017) | 0.9 | 0.009 (0.008; 0.010) | 0.4 | 0.009 (0.009; 0.010) | 0.4 | ^ | ^ |
Not treated with urate-lowering therapy | ^ | ^ | ^ | ^ | ^ | ^ | 0.133 (0.129; 0.138) | 35.2 |