Skip to main content

Table 1 Baseline characteristics of each group categorized by serum uric acid variability (measured by CV)

From: Visit-to-visit variability of serum uric acid measurements and the risk of all-cause mortality in the general population

Characteristics Total (N = 53,956) Quartile 1 (N = 13,483) Quartile 2 (N = 13,495) Quartile 3 (N = 13,492) Quartile 4 (N = 13,486) P value
Age, years 49.24 ± 11.83 49.71 ± 11.30 49.35 ± 11.61 49.05 ± 11.90 48.85 ± 12.45 < 0.0001
Male, n (%) 41,210 (76.38) 9790 (72.61) 10,037 (74.38) 10,372 (76.88) 11,011 (81.65) < 0.0001
High school or above, n (%) 4262 (7.9) 1086 (8.06) 1141 (8.46) 1061 (7.86) 974 (7.22) 0.0021
Income ≥ 1000 RMB, n (%) 8204 (15.2) 1933 (14.34) 2098 (15.55) 2122 (15.73) 2051 (15.21) 0.0075
Current smoker, n (%) 18,307 (33.93) 4204 (31.18) 4340 (32.16) 4640 (34.39) 5123 (37.99) < 0.0001
Current alcohol, n (%) 20,899 (38.73) 4720 (35.01) 5008 (37.11) 5326 (39.48) 5845 (43.34) < 0.0001
Active physical activity, n (%) 7746 (14.36) 1806 (13.39) 1924 (14.26) 2003 (14.85) 2013 (14.93) 0.0009
Hypertension, n (%) 6188 (11.47) 1330 (9.86) 1426 (10.57) 1564 (11.59) 1868 (13.85) < 0.0001
Diabetes mellitus, n (%) 1492 (2.77) 377 (2.80) 387 (2.87) 348 (2.58) 380 (2.82) 0.4848
Dyslipidemia, n (%) 3428 (6.35) 779 (5.78) 820 (6.08) 866 (6.42) 963 (7.14) < 0.0001
Antihypertensive agents, n (%) 5390 (9.99) 1143 (8.48) 1225 (9.08) 1370 (10.15) 1652 (12.25) < 0.0001
Hypoglycemic agents, n (%) 1153 (2.14) 292 (2.17) 308 (2.28) 267 (1.98) 286 (2.12) 0.3848
Lipid-lowering agents, n (%) 543 (1.01) 119 (0.88) 124 (0.92) 140 (1.04) 160 (1.19) 0.0543
Body mass index, kg/m2 25.08 ± 3.47 24.87 ± 3.46 24.96 ± 3.48 25.15 ± 3.45 25.36 ± 3.47 < 0.0001
Systolic blood pressure, mmHg 128.61 ± 19.93 127.56 ± 19.55 127.90 ± 19.54 128.48 ± 19.67 130.51 ± 20.80 < 0.0001
Diastolic blood pressure, mmHg 82.68 ± 11.37 81.95 ± 11.09 82.24 ± 11.21 82.63 ± 11.23 83.91 ± 11.84 < 0.0001
Fasting blood glucose, mmol/L 5.40 ± 1.55 5.34 ± 1.54 5.39 ± 1.58 5.39 ± 1.47 5.47 ± 1.61 < 0.0001
eGFR, mL/min/1.73 m2 84.06 ± 25.13 86.46 ± 28.23 84.13 ± 24.28 83.20 ± 25.11 82.46 ± 22.38 < 0.0001
hs-CRP, mg/L 2.34 ± 6.50 2.03 ± 5.23 2.11 ± 4.98 2.36 ± 7.45 2.87 ± 7.79 < 0.0001
Serum uric acid, μmol/L
 Baseline 286.36 ± 83.74 272.33 ± 68.36 280.05 ± 71.98 286.99 ± 79.16 306.08 ± 106.33 < 0.0001
 Mean 287.99 ± 72.43 272.52 ± 67.26 280.97 ± 68.16 289.62 ± 70.51 308.85 ± 78.23 < 0.0001
Serum uric acid variability       
 CV 16.30 ± 10.68 5.92 ± 2.71 11.84 ± 3.26 17.86 ± 4.82 29.58 ± 10.42 < 0.0001
 SD 45.75 ± 31.14 15.23 ± 5.76 31.46 ± 4.41 48.87 ± 5.89 87.43 ± 30.16 < 0.0001
 ARV 56.26 ± 40.36 19.41 ± 8.90 39.64 ± 11.27 60.67 ± 16.64 105.32 ± 44.43 < 0.0001
 VIM 9.07 ± 5.94 3.29 ± 1.51 6.59 ± 1.82 9.94 ± 2.68 16.47 ± 5.80 < 0.0001
  1. eGFR estimated glomerular filtration rate, hs-CRP high-sensitivity C-reactive protein, CV coefficient of variation, SD standard deviation, ARV average real variability, VIM variability independent of the mean
  2. Continuous variables are expressed as mean with standard deviation; categorical variables are expressed as frequency with percentage