Table 1 Baseline characteristics of each group categorized by serum uric acid variability (measured by CV)
Characteristics | Total (N = 53,956) | Quartile 1 (N = 13,483) | Quartile 2 (N = 13,495) | Quartile 3 (N = 13,492) | Quartile 4 (N = 13,486) | P value |
|---|---|---|---|---|---|---|
Age, years | 49.24 ± 11.83 | 49.71 ± 11.30 | 49.35 ± 11.61 | 49.05 ± 11.90 | 48.85 ± 12.45 | < 0.0001 |
Male, n (%) | 41,210 (76.38) | 9790 (72.61) | 10,037 (74.38) | 10,372 (76.88) | 11,011 (81.65) | < 0.0001 |
High school or above, n (%) | 4262 (7.9) | 1086 (8.06) | 1141 (8.46) | 1061 (7.86) | 974 (7.22) | 0.0021 |
Income ≥ 1000 RMB, n (%) | 8204 (15.2) | 1933 (14.34) | 2098 (15.55) | 2122 (15.73) | 2051 (15.21) | 0.0075 |
Current smoker, n (%) | 18,307 (33.93) | 4204 (31.18) | 4340 (32.16) | 4640 (34.39) | 5123 (37.99) | < 0.0001 |
Current alcohol, n (%) | 20,899 (38.73) | 4720 (35.01) | 5008 (37.11) | 5326 (39.48) | 5845 (43.34) | < 0.0001 |
Active physical activity, n (%) | 7746 (14.36) | 1806 (13.39) | 1924 (14.26) | 2003 (14.85) | 2013 (14.93) | 0.0009 |
Hypertension, n (%) | 6188 (11.47) | 1330 (9.86) | 1426 (10.57) | 1564 (11.59) | 1868 (13.85) | < 0.0001 |
Diabetes mellitus, n (%) | 1492 (2.77) | 377 (2.80) | 387 (2.87) | 348 (2.58) | 380 (2.82) | 0.4848 |
Dyslipidemia, n (%) | 3428 (6.35) | 779 (5.78) | 820 (6.08) | 866 (6.42) | 963 (7.14) | < 0.0001 |
Antihypertensive agents, n (%) | 5390 (9.99) | 1143 (8.48) | 1225 (9.08) | 1370 (10.15) | 1652 (12.25) | < 0.0001 |
Hypoglycemic agents, n (%) | 1153 (2.14) | 292 (2.17) | 308 (2.28) | 267 (1.98) | 286 (2.12) | 0.3848 |
Lipid-lowering agents, n (%) | 543 (1.01) | 119 (0.88) | 124 (0.92) | 140 (1.04) | 160 (1.19) | 0.0543 |
Body mass index, kg/m2 | 25.08 ± 3.47 | 24.87 ± 3.46 | 24.96 ± 3.48 | 25.15 ± 3.45 | 25.36 ± 3.47 | < 0.0001 |
Systolic blood pressure, mmHg | 128.61 ± 19.93 | 127.56 ± 19.55 | 127.90 ± 19.54 | 128.48 ± 19.67 | 130.51 ± 20.80 | < 0.0001 |
Diastolic blood pressure, mmHg | 82.68 ± 11.37 | 81.95 ± 11.09 | 82.24 ± 11.21 | 82.63 ± 11.23 | 83.91 ± 11.84 | < 0.0001 |
Fasting blood glucose, mmol/L | 5.40 ± 1.55 | 5.34 ± 1.54 | 5.39 ± 1.58 | 5.39 ± 1.47 | 5.47 ± 1.61 | < 0.0001 |
eGFR, mL/min/1.73 m2 | 84.06 ± 25.13 | 86.46 ± 28.23 | 84.13 ± 24.28 | 83.20 ± 25.11 | 82.46 ± 22.38 | < 0.0001 |
hs-CRP, mg/L | 2.34 ± 6.50 | 2.03 ± 5.23 | 2.11 ± 4.98 | 2.36 ± 7.45 | 2.87 ± 7.79 | < 0.0001 |
Serum uric acid, μmol/L | ||||||
 Baseline | 286.36 ± 83.74 | 272.33 ± 68.36 | 280.05 ± 71.98 | 286.99 ± 79.16 | 306.08 ± 106.33 | < 0.0001 |
 Mean | 287.99 ± 72.43 | 272.52 ± 67.26 | 280.97 ± 68.16 | 289.62 ± 70.51 | 308.85 ± 78.23 | < 0.0001 |
Serum uric acid variability | Â | Â | Â | Â | Â | Â |
 CV | 16.30 ± 10.68 | 5.92 ± 2.71 | 11.84 ± 3.26 | 17.86 ± 4.82 | 29.58 ± 10.42 | < 0.0001 |
 SD | 45.75 ± 31.14 | 15.23 ± 5.76 | 31.46 ± 4.41 | 48.87 ± 5.89 | 87.43 ± 30.16 | < 0.0001 |
 ARV | 56.26 ± 40.36 | 19.41 ± 8.90 | 39.64 ± 11.27 | 60.67 ± 16.64 | 105.32 ± 44.43 | < 0.0001 |
 VIM | 9.07 ± 5.94 | 3.29 ± 1.51 | 6.59 ± 1.82 | 9.94 ± 2.68 | 16.47 ± 5.80 | < 0.0001 |