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Table 2 Therapy duration of bisphosphonates

From: Bisphosphonates as disease-modifying drugs in osteoarthritis preclinical studies: a systematic review from 2000 to 2020

Animal model Short-term ( 2 months) Intermediate-term (2 to 6 months) Long term (≥6 months)
Reference Drug Duration Reference Drug Duration Reference Drug Duration
Rabbit She et al. [20] ZLN * Shirai et al. [23] ALN 3    
Lamproploulou et al. [21] ZLN 1
Permuy et al. [22] RIS 2
Zhang et al. [24] ALN 2
MacNeil et al. [25] RIS 1.5
Doschack et al. [26] RIS 1.5
Doschack et al. [27] RIS 1.5
Muehleman et al. [28] ZLN 2
Rat Cinar et al. [29] ZLN 1.5 Bagi et al. [30] ZLN 2.5    
Mohan et al. [32] ALN < 1 Zhu et al. [31] ALN 4.5
Panahafir et al. [33] ALN 2 Hayami et al. [37] ALN 2.5
Koh et al. [34] PAM 2
Strassle et al. [36] ZLN < 1
Jones et al. [35] ALN/RIS 2
Mice Adebayo et al. [38]
Khorasani et al. [39]
ALN
ALN
1.5
1
Sniekers et al. [40] ALN 3    
Guinea-Pig     Ding et al. [42] ALN 4.5 Thomsen et al. [41] RIS 6
Dog Moreau et al. [45] TLN 1.5 Pelletier et al. [44] TLN 3 Dearmin et al. [43] ZLN 12
  1. ALN alendronate, PAM pamidronate, RIS risedronate, ZLN zoledronic acid, TIL tiludronate. Duration in months. *Only once post-surgery