| |
2004
|
2009
|
2015
|
p value
|
---|
age
|
(year)
|
62.2
|
66.3
|
70.1
|
N/A
|
affected time
|
(year)
|
18.1
|
23.1
|
28.5
|
N/A
|
CRP
|
(mg/dl)
|
1.31
|
0.97
|
0.79
|
0.275
|
ESR
|
(mm/hr)
|
52.1
|
27.9*
|
34.7**
|
0.001
|
MMP-3
|
(ng/dl)
|
179.5
|
149.1
|
171.5
|
0.743
|
DAS28
| |
no data
|
3.17
|
3
|
0.32
|
- Numbers show the averages at each endpoint. Analysis of variance with post hoc Bonferroni test was used for multiple comparison
- CRP C-reactive protein, ESR erythrocyte sedimentation rate, MMP matrix metalloprotease, DAS disease activity score
- *: p = 0.001, *: p = 0.019