Table 2 Ingenuity pathway analysis (IPA)

 Name

p value

Overlap

  Altered T cell and B cell signalling in rheumatoid arthritis

1.41E− 10

17.3%, 14/81

  TREM1 signalling

2.53E− 10

18.6%, 13/70

  Dendritic cell maturation

5.68E− 08

9.5%, 16/169

  Allograft rejection signalling

1.39E− 07

18.8%, 9/48

  Communication between innate and adaptive immune cells

2.06E− 07

13.4%, 11/82

 Upstream regulator

  TGM2

  CEBPA

  CSF2

  TNF

  IRF4

 Name

p value

Molecules

  Immunological disease

6.30E− 03 to 1.20E− 22

151

  Connective tissue disorders

5.32E− 03 to 3.31E− 21

81

  Inflammatory disease

6.18E− 03 to 3.31E− 21

116

  Skeletal and muscular disorders

5.32E− 03 to 3.31E− 21

106

  Infectious diseases

5.76E− 03 to 5.84E− 20

76

 Name

p value

Molecules

  Cell-to-cell signalling and interaction

6.18E− 03 to 1.99E− 14

100

  Cell death and survival

7.09E− 03 to 3.79E− 10

97

  Cellular movement

6.44E− 03 to 4.26E− 10

55

  Cellular development

6.48E− 03 to 5.54E− 10

49

  Cellular growth and proliferation

6.18E− 03 to 5.54E− 10

84

 Name

p value

Molecules

  Haematological system development and function

6.48E− 03 to 6.44E− 13

72

  Immune cell trafficking

6.18E− 03 to 6.44E− 13

47

  Embryonic development

1.86E− 05 to 1.86E− 05

4

  Haematopoiesis

6.48E− 03 to 2.86E− 05

24

  Hair and skin development and function

6.18E− 03 to 4.26E− 05

10