Table 1 Patient and disease characteristics
Variable | Results |
|---|---|
Males, n (%) | 84 (51.9%) |
Age at diagnosis, years, mean ± SD | 60.9 ± 15.7 |
Follow-up period, years, mean ± SD | 5.4 ± 5.0 |
AAV type (n, %) | |
GPA | 102 (63%) |
MPA | 60 (37%) |
ANCA, n (%), n = 159 | |
C-/PR3-ANCA | 70 (44%) |
P-/MPO-ANCA | 69 (43%) |
Negative | 20 (13%) |
Severity, n (%) | |
Generalized | 129 (80%) |
Localized | 33 (20%) |
Organ involvement | |
Lung | 125 (77%) |
Kidney | 114 (70%) |
Joints | 78 (48%) |
ENT | 71 (44%) |
Nervous | 40 (25%) |
Skin | 37 (23%) |
Mucosal/eyes | 25 (15%) |
Other | 33 (20%) |
BVAS at diagnosis, mean ± SD | 12.75 ± 6.25 |
Dialysis, n (%) | 23 (14.2%) |
PLEX, n (%) | 10 (6.2%) |
Initial treatment (n, %) | |
CYC | 99 (61%) |
RTX | 29 (18%) |
MTX | 13 (8%) |
MMF | 3 (2%) |
RTX+CYC | 9 (6%) |
GC only | 9 (6%) |
Maintenance therapy after initial induction* (n, %) | |
AZA | 44 (38.1%) |
RTX | 43 (37.5%) |
MMF | 16 (13.9%) |
MTX | 10 (8.7%) |
Other | 2 (1.7%) |
Comorbidities (n, %) | |
Arterial hypertension | 70 (43%) |
Diabetes | 30 (18%) |
Cardiovascular disease (CVD) | 27 (17%) |
Depression | 17 (10%) |
Chronic obstructive pulmonary disease (COPD) | 11 (7%) |
Fracture | 9 (6%) |
Gastric ulcer | 7 (4%) |
Stroke | 3 (2%) |