Skip to main content

Table 2 Patients baseline characteristics and ATO efficacy at week 24

From: Safety and efficacy of low-dose intravenous arsenic trioxide in systemic lupus erythematosus: an open-label phase IIa trial (Lupsenic)

   

Baseline

ATO dosage mg/kg/d

Week 24

Patient no., gender, age (years)

SLE duration (years)

Previous IS

Concomitant treatment

Symptoms

SLEDAI

OCS

mg/d

Severe flare

SLEDAI

OCS

mg/d

W24 SRI-4-R

1. F, 35

12

MTX

HCQ, THAL, MTX

A, C

10

15

0.10

W24

8

10

No

2. F, 41

23

MTX

HCQ

A, C

12

15

0.10

No

2

2.5

Yes

3. F, 49

29

anti-Fcg-R mAb

HCQ

A, C

10

15

0.10

No

4

7

Yes

4. M, 37

2

MTX

HCQ, MTX

A, C

6

10

0.10

No

2

8

Yes

5. F, 47

26

CYC, Ci, MMF, RTX, THAL

HCQ

A

8

15

0.15

No

10

15

No

6. F, 30

4

BELI, MTX, EPRA, LEFLU,

HCQ

A, C

6

10

0.15

No

6

7.5

No

7. F, 50

14

MTX

HCQ

A

8

12.5

0.15

W20

20

2

No

8. H, 53

3

MTX

HCQ, MTX

A, C

8

10

0.20

No

0

5

Yes

9. F, 45

15

MTX, AZA, CYC

MMF

A, C

16

10

0.20

No

4

5

Yes

10. F, 23

6

AZA

HCQ, AZA

A, C

6

10

0.20

No

4

5

No

  1. ATO arsenic trioxide, AZA azathioprine, anti-Fcg-R mAb anti-Fc gamma-receptor monoclonal antibody, BELI belimumab, Ci ciclosporine, CYC cyclophosphamide, EPRA epratuzumab, HCQ hydroxychloroquine, IS immunosuppressant, LEFLU leflunomide, MTX methotrexate, MMF mycophenolate mofetil, OCS oral corticosteroids, RTX rituximab, THAL thalidomide, A articular, C cutaneous, SLEDAI Systemic Lupus Erythematosus Disease Activity Index, SRI-4-R SLE response index-4 response