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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Positive feedback regulation between USP15 and ERK2 inhibits osteoarthritis progression through TGF-β/SMAD2 signaling

Fig. 6

A working model for positive feedback regulation between USP15 and ERK2 playing a critical role in OA. Non-SMAD of ERK2 can promote TGF-β/SMAD2 signaling by increasing the level of USP15. Next, USP15 can interact with deubiquitinate and activate ERK2 to stimulate TGF-β/SMAD2 signaling. Finally, this positive feedback loop can inhibit OA progressions

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Arthritis Research & Therapy

ISSN: 1478-6362

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