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Table 3 Underlying therapeutic signaling pathway

From: Phenotypic alteration of macrophages during osteoarthritis: a systematic review

Signaling pathway

Interventional site

mTORC1-Rheb1/TSC1 [37]

Cartilage

Sirt1 [52]

Cartilage

CCL2-CCR2 [31]

Cartilage

Oxygen and hydrogen peroxide [54]

Synovium