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Table 1 Top 10 genes selected by TWAS analysis

From: Integrating transcriptome-wide association study and mRNA expression profile identified candidate genes related to hand osteoarthritis

Tissue

Gene name

Chromosome

TWAS.Z

TWAS.P

Muscle skeleton

ANKRD44

2

3.8381

0.0001

RIC3

11

3.6172

0.0003

AC005154.6

7

3.5112

0.0004

PARD3

10

3.4069

0.0007

GGCT

7

3.3363

0.0008

Peripheral blood

CRIM1

2

−3.6781

0.0002

ZNF880

19

3.6694

0.0002

NCKIPSD

3

−3.629

0.0003

CCR3

3

−3.5323

0.0004

R3HCC1

8

3.5037

0.0005

  1. Note: The GWAS summary data for hand OA was derived from the UK Biobank (UK Biobank fields: 20002), which contains 452,264 White British individuals, including 37,782 osteoarthritis patients. The TWAS. P and TWAS. Z values were calculated by the FUSION approach (http://gusevlab.org/projects/fusion/)
  2. TWAS Transcriptome-Wide Association Study, GWAS Genome-Wide Association Study, TWAS P TWAS P value, TWAS Z TWAS Z score