Tissue | Gene name | Chromosome | TWAS.Z | TWAS.P |
---|
Muscle skeleton | ANKRD44 | 2 | 3.8381 | 0.0001 |
RIC3 | 11 | 3.6172 | 0.0003 |
AC005154.6 | 7 | 3.5112 | 0.0004 |
PARD3 | 10 | 3.4069 | 0.0007 |
GGCT | 7 | 3.3363 | 0.0008 |
Peripheral blood | CRIM1 | 2 | −3.6781 | 0.0002 |
ZNF880 | 19 | 3.6694 | 0.0002 |
NCKIPSD | 3 | −3.629 | 0.0003 |
CCR3 | 3 | −3.5323 | 0.0004 |
R3HCC1 | 8 | 3.5037 | 0.0005 |
- Note: The GWAS summary data for hand OA was derived from the UK Biobank (UK Biobank fields: 20002), which contains 452,264 White British individuals, including 37,782 osteoarthritis patients. The TWAS. P and TWAS. Z values were calculated by the FUSION approach (http://gusevlab.org/projects/fusion/)
- TWAS Transcriptome-Wide Association Study, GWAS Genome-Wide Association Study, TWAS P TWAS P value, TWAS Z TWAS Z score