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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Diet-induced obesity leads to behavioral indicators of pain preceding structural joint damage in wild-type mice

Fig. 1

Chronic consumption of the high-fat and western diets increases adiposity in C57BL/6N mice. a At all timepoints, mice fed the high-fat and western diets showed significant increases in overall weight and in weight-gain from baseline compared to age-matched chow-fed controls. b Representative reconstructed micro-CT images of mice following 40 weeks of experimental diets. Isotropic surface-rendering of skeletal tissue (indicated in white) is overlaid with a mid-coronal slice where lean tissue is indicated in red and adipose tissue is indicated in yellow. c Quantitative micro-CT analysis of whole-body composition showed a significant increase in adiposity and significant decreases in both percentage of lean and skeletal and in mice fed the high-fat and western diet mice compared to age-matched chow-fed controls at all time points. A significant increase was also seen in bone mineral density in mice following consumption of the high-fat and western diets at the 24- and 40-week timepoints. n = 9–16 mice per timepoint, per diet. Data are displayed as mean ± 95% CI; data points for each mouse are graphed within each group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by 2-way ANOVA

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