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Table 1 Baseline characteristics of patients with AAV (n = 60)

From: Serum chitinase-3-like 1 protein is a useful biomarker to assess disease activity in ANCA-associated vasculitis: an observational study

 

Values

Classification, n (%)

 MPA

32 (53.3)

 GPA

17 (28.3)

 EGPA

11 (18.3)

Demographic data

 Age, years

59.4 (14.3)

 Female gender, n (%)

40 (66.7)

 New onset AAV, n (%)

23 (38.3)

 Disease duration, months†

2.4 (23.9)

AAV-related parameter

 BVAS†

7.0 (10.5)

 FFS (2009) †

1.0 (1.0)

 VDI†

3.0 (2.0)

 SF-36 PCS score

50.5 (22.4)

 SF-36 MCS score

58.3 (20.1)

Clinical features (organ involvement), n (%)

 General manifestation

17 (28.3)

 Cutaneous manifestation

7 (11.7)

 Mucous membrane and eye manifestation

3 (5.0)

 Ear, nose, and throat manifestation

25 (41.7)

 Pulmonary manifestation

37 (61.7)

 Cardiovascular manifestation

3 (5.0)

 Abdominal manifestation

1 (1.7)

 Renal manifestation

33 (55.0)

 Nervous system manifestation

12 (20.0)

ANCA positivity, n (%)

 ANCA double positivity

1 (1.7)

 MPO-ANCA (or P-ANCA) positivity

37 (61.7)

 PR3-ANCA (or C-ANCA) positivity

7 (11.7)

 ANCA negativity

17 (28.3)

Laboratory data

 White blood cell count, /mm3†

7345.0 (5380.0)

 Neutrophil count, /mm3†

5000.0 (4790.0)

 Platelet count, × 1000/mm3†

254.0 (139.0)

 ESR, mm/h†

30.0 (31.5)

 CRP, mg/L†

1.4 (8.1)

 Creatinine, mg/dL†

1.0 (1.4)

 AST, IU/L†

18.0 (7.0)

 ALT, IU/L†

18.5 (13.5)

 Serum YKL-40, ng/mL†

189.2 (190.7)

Concurrent immunosuppressive agents, n (%)

 Glucocorticoid

42 (70.0)

 Cyclophosphamide

8 (13.3)

 Rituximab

1 (1.7)

 Azathioprine

14 (23.3)

 Tacrolimus

3 (5.0)

 Mycophenolate mofetil

2 (3.3)

 Methotrexate

2 (3.3)

  1. Values are expressed as mean (standard deviation) or in number (percentages)
  2. †Continuous variables that were non-normally distributed are expressed as median (interquartile range)
  3. AAV ANCA-associated vasculitis, ANCA anti-neutrophil cytoplasmic antibody, MPA microscopic polyangiitis, GPA granulomatosis with polyangiitis, EGPA eosinophilic granulomatosis with polyangiitis, BVAS Birmingham vasculitis activity score, FFS Five factor score, VDI Vasculitis damage index, SF-36 Short form-36, PCS Physical component summary, MCS Mental component summary, MPO myeloperoxidase, P perinuclear, PR3 proteinase 3, C cytoplasmic, ESR erythrocyte sedimentation rate, CRP C-reactive protein, AST aspartate aminotransferase, ALT alanine aminotransferase