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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell formation, potentially contributing to premature atherosclerosis in SLE

Fig. 4

Effects of CMPK2 knockdown on BMDMs and Raw 264.7 cells stimulated by IFN-α. Raw 264.7 cells were treated with oxLDL in the presence or absence of IFN-α for 24 h. The expression of CMPK2 mRNA and protein was measured by qPCR and Western blotting, respectively (a). Foam cell formation was measured by oil red O staining (b), and BODIPY analysis was also carried out according to the description in the “Materials and methods” section (c). Similar analyses were performed with BMDMs (df). Asterisks indicate values that are significantly different from the relevant control (*P < 0.05, **P < 0.01, and ***P < 0.001)

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