Skip to main content
Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Stimulation of regulatory T cells with Lactococcus lactis expressing enterotoxigenic E. coli colonization factor antigen 1 retains salivary flow in a genetic model of Sjögren’s syndrome

Fig. 5

Treatment with L. lactis-CFA/I suppresses proinflammatory cytokines and augments regulatory cytokine production. Lymphocytes from a MLNs, b spleens, and c HNLNs were isolated from treatment groups described in Fig. 4. At study termination, purified lymphocytes from PBS-, LL vector (Vec.)-, and LL-CFA/I-treated mice were stimulated with anti-CD3 and anti-CD28 mAbs for 4 days for cytokine ELISA. Culture supernatants were analyzed for production of IL-6, IL-17, IFN-γ, IL-10, and TGF-β by cytokine-specific ELISAs. Depicted are the means ± SEM; *P < 0.05 and **P < 0.01 versus PBS-dosed mice

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us