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Table 2 Univariate and multivariate regression analysis in rheumatoid arthritis group (n = 90)

From: Impact of disease activity on impaired glucose metabolism in patients with rheumatoid arthritis

  logHOMA2-IR logHOMA2-%S logC-peptide
Univariate regression Multivariate regressionb Univariate regression Multivariate regressionb Univariate regression Multivariate regressionb
β P β P β P β P β P β P
Classic IR risk factors
 Age (years) 0.004 0.015 0.001 0.328 − 0.006 0.010 − 0.003 0.316 0.007 0.001 0.005 0.039
 BMI (kg/m2) 0.014 0.000 0.011 0.002 − 0.024 0.000 − 0.017 0.006 0.016 0.001 0.011 0.042
 TGLa (mmol/l) 0.501 0.000 0.314 0.020 − 0.982 0.000 − 0.654 0.006 0.584 0.004 0.302 0.144
 Hypertension, n (%) 0.053 0.091 − 0.007 0.837 − 0.102 0.060 0.001 0.985 0.086 0.062 −0.004 0.938
Inflammation markers
 ESRa (mm/h) 0.037 0.384 0.030 0.388 − 0.070 0.349 − 0.066 0.320 0.145 0.020 0.133 0.022
 CRPa (mg/l) 0.030 0.363 0.030 0.320 − 0.062 0.281 − 0.069 0.183 0.048 0.332 0.043 0.361
 IL-6a (pg/ml) 0.003 0.901 0.016 0.511 − 0.018 0.698 − 0.041 0.320 − 0.011 0.776 − 0.002 0.963
Parameters of RA activity
 MMP3a (ng/ml) 0.084 0.024 0.075 0.025 − 0.013 0.013 − 0.143 0.012 0.051 0.364 0.045 0.390
 DAS28-ESRa 0.194 0.041 0.206 0.014 − 0.335 0.043 − 0.354 0.014 0.232 0.102 0.248 0.058
 DAS28-CRPa 0.182 0.032 0.192 0.009 − 0.313 0.033 − 0.332 0.009 0.144 0.256 0.162 0.163
 DAS28-ESR ≥ 5.1 0.086 0.002 0.083 0.001 − 0.730 0.003 − 0.143 0.001 0.095 0.026 0.090 0.022
 HAQa 0.386 0.031 0.362 0.023 − 0.148 0.019 − 0.646 0.018 0.276 0.302 0.210 0.401
 VASa 0.132 0.034 0.148 0.007 − 0.228 0.035 − 0.249 0.008 0.001 0.269 0.111 0.199
 TJCa 0.118 0.015 0.121 0.005 − 0.205 0.014 − 0.206 0.005 0.059 0.418 0.068 0.312
 SJCa 0.006 0.202 0.056 0.175 − 0.106 0.192 − 0.094 0.181 0.031 0.661 0.024 0.709
  1. Two-tailed level of P < 0.05 was considered statistically significant and marked in bold
  2. Abbreviations: β unstandardized coefficient, BMI body mass index, CRP C-reactive protein, DAS28 disease activity score of 28 joints, ESR erythrocyte sedimentation rate, HAQ Health Assessment Questionnaire, HOMA2-IR Homeostasis Model Assessment of insulin resistance, HOMA2-%S Homeostasis Model Assessment of insulin sensitivity, IL interleukin, IR insulin resistance, MMP3 matrix metalloproteinase-3, RA rheumatoid arthritis, SJC number of swollen joints, TGL triglycerides, TJC number of tender joints, VAS visual analogue scale (0–100 mm)
  3. aLog values. bAdjusted for age, BMI, hypertension, and triglycerides