Impact of disease activity on impaired glucose metabolism in patients with rheumatoid arthritis

Ristić, Gorica G.; Subota, Vesna; Stanisavljević, Dejana; Vojvodić, Danilo; Ristić, Arsen D.; Glišić, Branislava; Petronijević, Milan; Stefanović, Dušan Z.

doi:10.1186/s13075-021-02476-0

Arthritis Research & Therapy

Table 2 Univariate and multivariate regression analysis in rheumatoid arthritis group (n = 90)

From: Impact of disease activity on impaired glucose metabolism in patients with rheumatoid arthritis

	logHOMA2-IR				logHOMA2-%S				logC-peptide
	Univariate regression		Multivariate regression^b		Univariate regression		Multivariate regression^b		Univariate regression		Multivariate regression^b
	β	P	β	P	β	P	β	P	β	P	β	P
Classic IR risk factors
Age (years)	0.004	0.015	0.001	0.328	− 0.006	0.010	− 0.003	0.316	0.007	0.001	0.005	0.039
BMI (kg/m²)	0.014	0.000	0.011	0.002	− 0.024	0.000	− 0.017	0.006	0.016	0.001	0.011	0.042
TGL^a (mmol/l)	0.501	0.000	0.314	0.020	− 0.982	0.000	− 0.654	0.006	0.584	0.004	0.302	0.144
Hypertension, n (%)	0.053	0.091	− 0.007	0.837	− 0.102	0.060	0.001	0.985	0.086	0.062	−0.004	0.938
Inflammation markers
ESR^a (mm/h)	0.037	0.384	0.030	0.388	− 0.070	0.349	− 0.066	0.320	0.145	0.020	0.133	0.022
CRP^a (mg/l)	0.030	0.363	0.030	0.320	− 0.062	0.281	− 0.069	0.183	0.048	0.332	0.043	0.361
IL-6^a (pg/ml)	0.003	0.901	0.016	0.511	− 0.018	0.698	− 0.041	0.320	− 0.011	0.776	− 0.002	0.963
Parameters of RA activity
MMP3^a (ng/ml)	0.084	0.024	0.075	0.025	− 0.013	0.013	− 0.143	0.012	0.051	0.364	0.045	0.390
DAS28-ESR^a	0.194	0.041	0.206	0.014	− 0.335	0.043	− 0.354	0.014	0.232	0.102	0.248	0.058
DAS28-CRP^a	0.182	0.032	0.192	0.009	− 0.313	0.033	− 0.332	0.009	0.144	0.256	0.162	0.163
DAS28-ESR ≥ 5.1	0.086	0.002	0.083	0.001	− 0.730	0.003	− 0.143	0.001	0.095	0.026	0.090	0.022
HAQ^a	0.386	0.031	0.362	0.023	− 0.148	0.019	− 0.646	0.018	0.276	0.302	0.210	0.401
VAS^a	0.132	0.034	0.148	0.007	− 0.228	0.035	− 0.249	0.008	0.001	0.269	0.111	0.199
TJC^a	0.118	0.015	0.121	0.005	− 0.205	0.014	− 0.206	0.005	0.059	0.418	0.068	0.312
SJC^a	0.006	0.202	0.056	0.175	− 0.106	0.192	− 0.094	0.181	0.031	0.661	0.024	0.709

Two-tailed level of P < 0.05 was considered statistically significant and marked in bold
Abbreviations: β unstandardized coefficient, BMI body mass index, CRP C-reactive protein, DAS28 disease activity score of 28 joints, ESR erythrocyte sedimentation rate, HAQ Health Assessment Questionnaire, HOMA2-IR Homeostasis Model Assessment of insulin resistance, HOMA2-%S Homeostasis Model Assessment of insulin sensitivity, IL interleukin, IR insulin resistance, MMP3 matrix metalloproteinase-3, RA rheumatoid arthritis, SJC number of swollen joints, TGL triglycerides, TJC number of tender joints, VAS visual analogue scale (0–100 mm)
^aLog values. ^bAdjusted for age, BMI, hypertension, and triglycerides

Back to article page

ISSN: 1478-6362

Contact us

Submission enquiries: arlene.pura@springernature.com
General enquiries: info@biomedcentral.com