Fig. 2
From: Periostin loss-of-function protects mice from post-traumatic and age-related osteoarthritis
Postn−/− mice are protected from post-traumatic OA. a Histological analysis of the cartilage showed that DMM-operated limbs exhibited increased cartilage degeneration than non-operated control limbs. Cartilage degeneration in wt mice was markedly higher (dotted boxes) than Postn−/− mice (arrows). b Semi-quantitative analysis of cartilage degeneration by maximum OARSI score showed that Postn−/− mice (n = 8) had significantly less maximum OARSI score than wt mice (n = 8). (Mann-Whitney test). c Semi-quantitative analysis of cartilage degeneration by summed OARSI score showed that Postn−/− mice (n = 8) had significantly less summed OARSI score than wt mice (n = 8). (Mann-Whitney test). d Synovitis was evaluated by measuring synovial lining cell layer and density of cells in the synovial stroma. e Semi-quantification of synovitis score was significantly lower in Postn−/− mice (n = 6) than wt mice (n = 6). (Mann-Whitney test). f μCT analysis showed that Postn−/− mice (n = 10) had significantly lower BV/TV. vBMD, Tb.Th and Tb.N and significantly higher Tb. Sp than wt mice (n = 10) in the DMM-operated limb (Mann-Whitney test)