Fig. 3
From: Periostin loss-of-function protects mice from post-traumatic and age-related osteoarthritis
Postn−/− mice are protected from age-related spontaneous OA. a Histological analysis of cartilage showed that wt mice developed significant cartilage degeneration at 24-month of age whereas age-matched Postn−/− mice did not develop any degeneration in the articular cartilage. b Semi-quantitative analysis of cartilage degeneration using maximum OARSI score displayed that Postn−/− mice (n = 7) had significantly less maximum OARSI score than wt mice (n = 6) (Mann-Whitney test). c Semi-quantitative analysis of cartilage degeneration using summed OARSI score displayed that Postn−/− mice (n = 7) had significantly less summed OARSI score than wt mice (n = 6) (Mann-Whitney test). d Synovitis was assessed by semi-quantiative analysis of synovial lining cell layer and density of cells in the synovial stroma. e Semi-quantification of synovitis score was not significantly different between the genotypes (n = 6 each). (Mann-Whitney test). f μCT analysis showed that Postn−/− mice (n = 5–7) had significantly lower BV/TV, vBMD, Tb.Th, and Tb.N and higher Tb. Sp than wt mice (n = 5–6) in the DMM-operated limbs (Mann-Whitney test)