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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice

Fig. 2

CCR2RA delivered systemically at different time points after DMM surgery. a 4, b 8, and c 16 weeks after DMM surgery, CCR2RA (RS504393, Tocris: 5 mg/kg, i.p., n = 5) or vehicle control (100% DMSO4, i.p., n = 4) was systemically administered and knee hyperalgesia was measured before injection, 1 h after, and 2 h after injection. **p < 0.01, ****p < 0.0001 vs vehicle. Repeated measures two-way ANOVA with Bonferroni’s multiple comparisons test to compare CCR2-RA to vehicle at each time point. Mean ± SEM

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Arthritis Research & Therapy

ISSN: 1478-6362

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