Table 1 Genetically predicted age at menarche, age at menopause and, age at first birth with the risk of rheumatoid arthritis. Results from primary Mendelian randomization analysis as well as sensitivity analyses based on a subset of instruments
Methods | #SNP | OR (95% CI) | P-value | #SNP | OR (95% CI) | P-value | #SNP | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|---|---|---|
Full set | Remove palindromic SNPs | Remove confounding SNPs | |||||||
Age at menarche | |||||||||
IVW | 340 | 1.06 (0.98–1.15) | 0.11 | 284 | 1.06 (0.97–1.15) | 0.19 | 283 | 1.03 (0.94–1.12) | 0.57 |
Maximum likelihood | 340 | 1.07 (1.00–1.14) | 0.06 | 284 | 1.06 (0.99–1.14) | 0.12 | 283 | 1.03 (0.95–1.11) | 0.50 |
MR-Egger | 340 | 1.11 (0.90–1.36) | 0.34 | 284 | 1.08 (0.85–1.37) | 0.51 | 283 | 0.97 (0.72–1.30) | 0.83 |
MR-Egger intercept | 0.69 | 0.85 | 0.68 | ||||||
Weighted median | 340 | 1.08 (0.97–1.21) | 0.15 | 284 | 1.10 (0.97–1.25) | 0.12 | 283 | 1.01 (0.90–1.14) | 0.86 |
Age at natural menopause | |||||||||
IVW | 54 | 1.05 (0.98–1.11) | 0.15 | 47 | 1.05 (0.98–1.13) | 0.13 | 42 | 1.04 (0.95–1.14) | 0.40 |
Maximum likelihood | 54 | 1.05 (1.02–1.08) | 4 × 10−3 | 47 | 1.06 (1.02–1.10) | 9 × 10−4 | 42 | 1.05 (1.00–1.10) | 0.05 |
MR-Egger | 54 | 1.04 (0.90–1.20) | 0.61 | 47 | 1.05 (0.90–1.23) | 0.51 | 42 | 1.05 (0.74–1.48) | 0.79 |
MR-Egger intercept | 0.92 | 0.99 | 0.96 | ||||||
Weighted median | 54 | 1.03 (0.98–1.08) | 0.30 | 47 | 1.05 (1.00–1.11) | 0.07 | 42 | 0.94 (0.88–1.01) | 0.09 |
Age at first birth | |||||||||
IVW | 10 | 0.85 (0.65–1.10) | 0.22 | 9 | 0.81 (0.61–1.07) | 0.14 | NA | NA | NA |
Maximum likelihood | 10 | 0.84 (0.73–0.97) | 0.02 | 9 | 0.81 (0.70–0.94) | 5 × 10−3 | NA | NA | NA |
MR-Egger | 10 | 3.32 (0.36–30.81) | 0.32 | 9 | 3.05 (0.33–28.49) | 0.36 | NA | NA | NA |
MR-Egger intercept | 0.26 | 0.28 | NA | NA | NA | ||||
Weighted median | 10 | 0.90 (0.73–1.10) | 0.30 | 9 | 0.85 (0.69–1.05) | 0.13 | NA | NA | NA |