Risk of gout among Taiwanese adults with ALDH-2 rs671 polymorphism according to BMI and alcohol intake

Table 2 Association of alcohol drinking, BMI, and ALDH2 rs671 polymorphism with gout

Variables	OR	95% CI	p-value
Alcohol drinking (ref, no)
Yes	1.297	1.098–1.532	0.0022
Body mass index (ref, normal)
Abnormal	1.550	1.368–1.755	< 0.0001
ALDH2 rs671 genotype (ref, GG)
GA+AA	0.887	0.800–0.984	0.0240
Sex (ref, women)
Men	2.363	2.068–2.700	< 0.0001
Age group (ref, 30–40 years)
41–50	0.710	0.614–0.821	< 0.0001
51–60	0.847	0.731–0.981	0.0272
61–70	0.871	0.733–1.034	0.1155
Waist-hip ratio (ref, normal)
Abnormal	1.358	1.212–1.522	< 0.0001
Body fat (ref, normal)
Abnormal	1.445	1.272–1.640	< 0.0001
Cigarette smoking status (ref, never)
Former	0.939	0.800–1.102	0.4409
Current	0.791	0.667–0.939	0.0073
Coffee consumption (ref, no)
Yes	1.066	0.955–1.190	0.2536
Tea consumption (ref, no)
Yes	1.223	1.099–1.361	0.0002
Exercise (ref, no)
Yes	1.035	0.927–1.157	0.5380
Diet status (ref, non-vegetarian)
Former vegetarian	1.013	0.792–1.296	0.9169
Vegan	0.656	0.497–0.867	0.0030
Blood urea nitrogen (ref, normal)
Abnormal	1.420	1.118–1.803	0.0041
Creatinine (ref, normal)
Abnormal	5.320	2.846–9.945	< 0.0001
HDL-C	0.980	0.975–0.985	< 0.0001
LDL-C	1.006	1.005–1.008	< 0.0001
Triglycerides	1.003	1.002–1.004	< 0.0001

Interaction between BMI and alcohol drinking (p-value = 0.0006)
BMI body mass index, OR odds ratio, CI confidence interval, ref reference, ALDH2 aldehyde dehydrogenase 2, HDL-C high-density lipoprotein cholesterol, LDC-C low-density lipoprotein cholesterol

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