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Table 3 Association of alcohol drinking and BMI with gout stratified by ALDH2 rs671 genotypes

From: Risk of gout among Taiwanese adults with ALDH-2 rs671 polymorphism according to BMI and alcohol intake

Variables

GG (n = 4660)

GA+AA (n = 4593)

OR

95% CI

p-value

OR

95% CI

p-value

Alcohol drinking (ref, no)

 Yes

1.289

1.048–1.586

0.0162

1.273

0.950–1.706

0.1062

Body mass index (ref, normal)

 Abnormal

1.584

1.332–1.883

< 0.0001

1.518

1.268–1.818

< 0.0001

Sex (ref, women)

 Men

2.322

1.924–2.802

< 0.0001

2.378

1.966–2.876

< 0.0001

Age group (ref, 30–40 years)

 41–50

0.633

0.516–0.776

< 0.0001

0.800

0.649–0.986

0.0362

 51–60

0.798

0.649–0.981

0.0318

0.899

0.727–1.111

0.0248

 61–70

0.917

0.722–1.164

0.4750

0.821

0.640–1.054

0.1215

Waist-hip ratio (ref, normal)

 Abnormal

1.301

1.109–1.526

0.0012

1.419

1.205–1.670

< 0.0001

Body fat (ref, normal)

 Abnormal

1.469

1.230–1.755

< 0.0001

1.414

1.178–1.698

0.0002

Cigarette smoking status (ref, never)

 Former

1.081

0.865–1.351

0.4948

0.811

0.644–1.023

0.0769

 Current

0.916

0.720–1.165

0.4745

0.698

0.546–0.892

0.0041

Coffee consumption (ref, no)

 Yes

1.142

0.981–1.329

0.0878

0.991

0.845–1.163

0.9141

Tea consumption (ref, no)

 Yes

1.195

1.029–1.388

0.0197

1.263

1.084–1.472

0.0028

Exercise (ref, no)

 Yes

0.996

0.854–1.162

0.9594

1.084

0.924–1.272

0.3232

Diet status (ref, non-vegetarian)

 Former vegetarian

1.172

0.828–1.660

0.3704

0.869

0.612–1.234

0.4317

 Vegan

0.647

0.437–0.959

0.0299

0.657

0.443–0.975

0.0370

Blood urea nitrogen (ref, normal)

 Abnormal

1.268

0.900–1.786

0.1744

1.558

1.113–2.182

0.0098

Creatinine (ref, normal)

 Abnormal

6.216

2.738–14.111

< 0.0001

4.418

1.630–11.972

0.0035

HDL-C

0.981

0.974–0.988

< 0.0001

0.979

0.971–0.987

< 0.0001

LDL-C

1.007

1.005–1.009

< 0.0001

1.006

1.003–1.008

< 0.0001

Triglycerides

1.003

1.002–1.004

< 0.0001

1.003

1.002–1.004

< 0.0001

  1. Interaction between BMI and alcohol drinking (p-value = 0.0102 and 0.0175 for the GG and GA+AA group, respectively)
  2. BMI body mass index, OR odds ratio, CI confidence interval, ref reference, ALDH2 Aldehyde dehydrogenase 2, HDL-C high-density lipoprotein cholesterol, LDC-C low-density lipoprotein cholesterol
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Arthritis Research & Therapy

ISSN: 1478-6362

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