Risk of gout among Taiwanese adults with ALDH-2 rs671 polymorphism according to BMI and alcohol intake

Table 4 Association between alcohol drinking and gout among participants with the ALDH2 rs671 GG genotype stratified by BMI

Variables	GG genotype (n = 4660)
	Normal (n = 2239)			Abnormal (n = 2421)
	OR	95% CI	P-value	OR	95% CI	P-value
Alcohol drinking (ref: no)
yes	1.533	1.036-2.269	0.0325	1.205	0.945-1.538	0.1331
Sex (ref: women)
men	2.742	1.996-3.765	<0.0001	2.116	1.671-2.681	<0.0001
Age group (ref: 30-40 years)
41-50	0.711	0.492-1.028	0.0697	0.578	0.450-0.742	<0.0001
51-60	1.064	0.740-1.531	0.7370	0.638	0.495-0.823	0.0005
61-70	0.906	0.591-1.391	0.6533	0.850	0.634-1.141	0.2792
Waist-hip ratio (ref: normal)
abnormal	1.647	1.246-2.177	0.0005	1.166	0.959-1.418	0.1236
Body fat (ref: normal)
abnormal	1.244	0.900-1.718	0.1861	1.595	1.282-1.985	<0.0001
Cigarette smoking status (ref: never)
former	1.098	0.720-1.675	0.6640	1.121	0.861-1.459	0.3961
current	1.032	0.666-1.600	0.8881	0.839	0.629-1.120	0.2344
Coffee consumption (ref: no)
yes	1.235	0.946-1.611	0.1207	1.112	0.922-1.341	0.2660
Tea consumption (ref: no)
yes	1.237	0.946-1.618	0.1204	1.181	0.985-1.416	0.0721
Exercise (ref: no)
yes	1.303	0.995-1.706	0.0545	0.860	0.712-1.039	0.1180
Diet status (ref: non-vegetarian)
former vegetarian	0.770	0.386-1.539	0.4603	1.480	0.966-2.268	0.0716
vegan	0.689	0.383-1.238	0.2124	0.554	0.323-0.950	0.0318
Blood urea nitrogen (ref: normal)
abnormal	0.865	0.441-1.694	0.6721	1.544	1.028-2.319	0.0363
Creatinine (ref: normal)
abnormal	19.851	3.691-106.761	0.0005	3.885	1.542-9.790	0.0040
HDL-C	0.980	0.969-0.991	0.0006	0.981	0.973-0.990	<0.0001
LDL-C	1.010	1.006-1.014	<0.0001	1.005	1.002-1.008	0.0004
Triglycerides	1.004	1.002-1.006	<0.0001	1.002	1.001-1.003	<0.0001

BMI body mass index, OR odds ratio, ref reference, ALDH2 aldehyde dehydrogenase 2, HDL-C high density lipoprotein cholesterol, LDC-C low density lipoprotein cholesterol

ISSN: 1478-6362