Risk of gout among Taiwanese adults with ALDH-2 rs671 polymorphism according to BMI and alcohol intake

Table 5 Association between alcohol drinking and gout among participants with the ALDH2 rs671 GA+AA genotype stratified by BMI

Variables	GA+AA genotype (n = 4593)
	Normal (n = 2216)			Abnormal (n = 2377)
	OR	95% CI	p-value	OR	95% CI	p-value
Alcohol drinking (ref, no)
Yes	2.109	1.202–3.699	0.0092	1.108	0.789–1.557	0.5525
Sex (ref, women)
Men	2.561	1.854–3.539	< 0.0001	2.190	1.724–2.780	< 0.0001
Age group (ref, 30–40 years)
41–50	1.119	0.766–1.635	0.5601	0.664	0.514–0.857	0.0017
51–60	1.329	0.905–1.951	0.1469	0.743	0.572–0.965	0.0260
61–70	1.536	0.991–2.382	0.0552	0.589	0.433–0.803	0.0008
Waist-hip ratio (ref, normal)
Abnormal	1.410	1.063–1.869	0.0171	1.441	1.176–1.766	0.0004
Body fat (ref, normal)
Abnormal	1.331	0.955–1.856	0.0913	1.392	1.113–1.742	0.0038
Cigarette smoking status (ref, never)
Former	0.527	0.326–0.851	0.0088	0.950	0.725–1.243	0.7065
Current	0.890	0.580–1.365	0.5936	0.591	0.438–0.798	0.0006
Coffee consumption (ref, no)
Yes	0.955	0.720–1.268	0.7516	0.996	0.820–1.211	0.9712
Tea consumption (ref, no)
Yes	1.562	1.193–2.046	0.0012	1.150	0.953–1.387	0.1454
Exercise (ref, no)
Yes	1.155	0.873–1.527	0.3127	1.024	0.841–1.248	0.8108
Diet status (ref, non-vegetarian)
Former vegetarian	0.443	0.200–0.979	0.0442	1.090	0.721–1.650	0.6821
Vegan	0.492	0.247–0.980	0.0437	0.765	0.466–1.254	0.2876
Blood urea nitrogen (ref, normal)
Abnormal	2.231	1.313–3.791	0.0030	1.217	0.792–1.871	0.3696
Creatinine (ref, normal)
Abnormal	1.715	0.407–7.234	0.4626	10.705	2.082–55.046	0.0045
HDL-C	0.979	0.967–0.991	0.0007	0.979	0.969–0.989	< 0.0001
LDL-C	1.006	1.002–1.010	0.0053	1.006	1.003–1.009	0.0002
Triglycerides	1.004	1.002–1.005	< 0.0001	1.003	1.002–1.004	< 0.0001

BMI body mass index, OR odds ratio, CI confidence interval, ref reference, ALDH2 aldehyde dehydrogenase 2, HDL-C high-density lipoprotein cholesterol, LDC-C low-density lipoprotein cholesterol

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