Table 6 Risk of gout in relation to the combination of BMI and alcohol drinking among participants stratified by ALDH2 rs671 genotypes
Variables | GG (n = 4660) | GA+AA (n = 4593) | ||||
|---|---|---|---|---|---|---|
OR | 95% CI | p-value | OR | 95% CI | p-value | |
BMI and alcohol drinking (ref, normal BMI and no alcohol drinking) | ||||||
 Normal BMI and alcohol drinking | 1.851 | 1.316–2.603 | 0.0004 | 2.212 | 1.302–3.757 | 0.0033 |
 Abnormal BMI and no alcohol drinking | 1.727 | 1.433–2.080 | < 0.0001 | 1.592 | 1.323–1.916 | < 0.0001 |
 Abnormal BMI and alcohol drinking | 1.913 | 1.451–2.523 | < 0.0001 | 1.675 | 1.166–2.407 | 0.0053 |
Sex (ref, women) | ||||||
 Men | 2.312 | 1.915–2.790 | < 0.0001 | 2.377 | 1.965–2.876 | < 0.0001 |
Age group (ref, 30–40 years) | ||||||
 41–50 | 0.633 | 0.516–0.777 | < 0.0001 | 0.798 | 0.648–0.983 | 0.0343 |
 51–60 | 0.798 | 0.649–0.981 | 0.0320 | 0.904 | 0.731–1.118 | 0.3501 |
 61–70 | 0.914 | 0.720–1.161 | 0.4632 | 0.820 | 0.639–1.052 | 0.1189 |
Waist-hip ratio (ref, normal) | ||||||
 Abnormal | 1.304 | 1.111–1.529 | 0.0011 | 1.426 | 1.211–1.679 | < 0.0001 |
Body fat (ref, normal) | ||||||
 Abnormal | 1.479 | 1.237–1.767 | < 0.0001 | 1.415 | 1.178–1.699 | 0.0002 |
Cigarette smoking status (ref, never) | ||||||
 Former | 1.078 | 0.863–1.347 | 0.5082 | 0.810 | 0.643–1.021 | 0.0745 |
 Current | 0.903 | 0.710–1.149 | 0.4079 | 0.692 | 0.541–0.884 | 0.0033 |
Coffee consumption (ref, no) | ||||||
 Yes | 1.131 | 0.971–1.317 | 0.1130 | 0.984 | 0.839–1.155 | 0.8477 |
Tea consumption (ref, no) | ||||||
 Yes | 1.192 | 1.026–1.384 | 0.0215 | 1.266 | 1.086–1.476 | 0.0026 |
Exercise (ref, no) | ||||||
 Yes | 1.001 | 0.858–1.168 | 0.9904 | 1.084 | 0.924–1.272 | 0.3235 |
Diet status (ref, non-vegetarian) | ||||||
 Former vegetarian | 1.155 | 0.815–1.636 | 0.4186 | 0.869 | 0.612–1.234 | 0.4333 |
 Vegan | 0.641 | 0.433–0.950 | 0.0267 | 0.663 | 0.447–0.985 | 0.0417 |
Blood urea nitrogen (ref, normal) | ||||||
 Abnormal | 1.279 | 0.909–1.801 | 0.1576 | 1.561 | 1.114–2.187 | 0.0097 |
Creatinine (ref, normal) | ||||||
 Abnormal | 6.192 | 2.726–14.067 | < 0.0001 | 4.449 | 1.639–12.076 | 0.0034 |
HDL-C | 0.980 | 0.973–0.987 | < 0.0001 | 0.979 | 0.972–0.987 | < 0.0001 |
LDL-C | 1.007 | 1.005–1.009 | < 0.0001 | 1.006 | 1.003–1.008 | < 0.0001 |
Triglycerides | 1.003 | 1.002–1.004 | < 0.0001 | 1.003 | 1.002–1.004 | < 0.0001 |