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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Early detection of osteoarthritis in the rat with an antibody specific to type II collagen modified by reactive oxygen species

Fig. 3

Partial co-localization of CX and oxPTM-CII staining in the cartilage of the medial tibial plateau and condyle in the DMM model. Toluidin blue and saffron du Gatinais, type X collagen (blue, CX) and oxPTM type II collagen (brown, oxPTM-CII) staining are shown for cartilage of the medial tibial plateau presenting different levels of degeneration: a, b loss of matrix staining but no defect (both from day 14) and c, d cartilage with a small and a large defect, respectively (from day 5 and 28, respectively). One example of staining for cartilage form the medial condyle is shown in e. Black arrows show examples of chondrocytes positive for oxPTM-CII but negative for CX

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