Fig. 3From: Early detection of osteoarthritis in the rat with an antibody specific to type II collagen modified by reactive oxygen speciesPartial co-localization of CX and oxPTM-CII staining in the cartilage of the medial tibial plateau and condyle in the DMM model. Toluidin blue and saffron du Gatinais, type X collagen (blue, CX) and oxPTM type II collagen (brown, oxPTM-CII) staining are shown for cartilage of the medial tibial plateau presenting different levels of degeneration: a, b loss of matrix staining but no defect (both from day 14) and c, d cartilage with a small and a large defect, respectively (from day 5 and 28, respectively). One example of staining for cartilage form the medial condyle is shown in e. Black arrows show examples of chondrocytes positive for oxPTM-CII but negative for CXBack to article page