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Table 3 HRpQCT parameters among patients with RA, by fracture status

From: Bone mineral density and microarchitecture among Chinese patients with rheumatoid arthritis: a cross-sectional study with HRpQCT

 

Distal radius

Distal tibia

Fracture

n = 11

No fracture

n = 70

P

Fracture

N = 11

No fracture

N = 70

P

Geometry

 Tt.Ar, mm2

312.2 ± 89.0

275.9 ± 62.1

0.095

755.3 ± 135.4

705.6 ± 127.1

0.236

 Ct.Ar, mm2

54.4 ± 15.3

58.0 ± 13.7

0.422

89.8 ± 24.3

103.8 ± 28.3

0.125

 Tb.Ar, mm2

262.8 ± 91.1

221.6 ± 58.3

0.049

671.1 ± 130.6

606.8 ± 122.0

0.112

 Ct.Pm, mm

77.9 ± 13.4

70.0 ± 8.8

0.012

107.3 ± 9.6

103.3 ± 9.4

0.204

Volumetric BMD, mgHA/ccm

 Tt.vBMD

195.5 ± 81.1

268.4 ± 79.6

0.006

163.0 ± 45.9

226.9 ± 61.7

0.002

 Ct.vBMD

765.3 ± 180.7

901.4 ± 84.7

0.032

801.8 ± 76.7

869.0 ± 88.8

0.020

 Tb.vBMD

68.6 ± 41.5

98.5 ± 41.8

0.030

78.8 ± 28.4

114.1 ± 35.8

0.003

Microarchitecture

 BV/TV

0.117 ± 0.049

0.149 ± 0.056

0.076

0.143 ± 0.034

0.185 ± 0.047

0.006

 Tb.Th, mm

0.220 ± 0.016

0.219 ± 0.020

0.795

0.243 ± 0.019

0.241 ± 0.019

0.698

 Tb.N, 1/mm

0.838 ± 0.336

1.126 ± 0.309

0.006

0.903 ± 0.255

1.150 ± 0.214

0.001

 Tb.Sp, mm

1.089(0.892–1.641)

0.875(0.715–1.074)

0.014

1.210(0.841–1.503)

0.849(0.767–1.037)

0.005

 Tb.1/N.SD

0.522(0.429–1.179)

0.349(0.280–0.478)

0.004

0.539(0.324–0.975)

0.353(0.287–0.466)

0.007

 Ct.Th, mm

0.854 ± 0.370

0.997 ± 0.231

0.084

0.988 ± 0.277

1.194 ± 0.304

0.039

 Ct.Po,%

0.60(0.40–1.50)

0.30(0.60–0.90)

0.427

2.50(1.60–4.00)

2.30(1.25–3.95)

0.670

μFEA*

 Stiffness, kN/mm

41.8 ± 19.0

46.6 ± 16.2

0.540

109.8 ± 25.3

131.2 ± 40.9

0.155

 Failure Load, N

2201 ± 982

2506 ± 937

0.476

6118 ± 1378

7233 ± 2277

0.180

  1. HRpQCT parameters at the distal radius and tibia were compared between patients with and without fractures in the RA group. Significant differences were shown in parameters regarding bone geometry, BMD, and microarchitecture
  2. *Performed in 11 patients with fracture and 11 age-and sex-matched patients without fracture