Fig. 4From: Cold-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1β productionMSU induces caspase-1 (p20) synthesis from CIRP-primed neutrophils. Neutrophils (2 × 106/ml) were pretreated with various concentrations of CIRP for 6 h. After pretreatment, the cells were stimulated MSU (200 μg/ml) for 18 h and supernatants were analyzed for the presence of caspase-1 (p20) by ELISA. Single asterisk indicates significant difference was observed at a threshold of p < 0.01compared to unstimulated control neutrophilsBack to article page