Fig. 1
From: Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activation
Tofacitinib strongly downregulates antiviral peptides but only minimally affects gene expression of antimicrobial peptides. a Keratinocytes were stimulated with tofacitinib (600 nM) or left untreated (control). The cells were harvested after 24 h; RNA was isolated from cell lysates and used for DNA MicroArray. Blue colour indicates upregulated genes, while red colour indicates downregulated genes compared to baseline. b Network analysis focusing on antimicrobial and antiviral genes