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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Identification of neutrophil β2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses

Fig. 2

Upregulation of the molecules involved in integrin-mediated cell adhesion in AAV. a Volcano plot of 3770 differentially expressed genes between patients with AAV and the healthy controls (HCs) (fold change > 1.3, adjusted P < 0.05). b Top five pathways that were differentially regulated between patients with AAV and HCs. c Z-score variance of representative genes within each integrin family among patients with each type of vasculitis and the HCs, are shown. *P < 0.05 using the Kruskal-Wallis test. MPA, microscopic polyangiitis; GPA, granulomatosis with polyangiitis; EGPA, eosinophilic polyangiitis; RV, rheumatoid vasculitis; PAN, polyarteritis nodosa; TAK, Takayasu arteritis; ILK, integrin-linked kinase; ITGAM, integrin alpha M; ITFG1, integrin alpha FG-GAP repeat containing 1; ITGB3, integrin beta 3; ITGA2B, integrin alpha 2b; ITGB2, integrin beta 2

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Arthritis Research & Therapy

ISSN: 1478-6362

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