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Table 1 Baseline characteristics of patients, assessed using FACS analysis

From: Identification of neutrophil β2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses

Variable AAV LVV PAN HC
n = 48 n = 26 n = 4 n = 17
Baseline characteristics
 Age, years 70 (57–80) 67 (47–72) 64 (48–72) 43 (32–56)
 Male, n (%) 15 (31) 14 (54) 1 (25) 5 (29)
 Race, Japanese, n (%) 48 (100) 26 (100) 4 (100) 17 (100)
 MPA/GPA/EGPA, n 20/19/9
 GCA/TAK, n 15/11
 Newly diagnosed/major relapse, n 45/3 24/2 4/0
 BVAS 12 (8–18) 3 (3–6) 15 (12–19)
Organ involvement
 Systemic, n (%) 34 (71) 23 (88) 2 (50)
 Skin, n (%) 5 (10) 1 (4) 3 (75)
 Mucous membranes/eyes, n (%) 5 (10) 0 (0) 0 (0)
 Ear, nose, throat, n (%) 22 (46) 0 (0) 0 (0)
 Chest, n (%) 28 (58) 0 (0) 1 (25)
 Vascular, n (%) 3 (6) 9 (35) 1 (25)
 Renal, n (%) 17 (35) 3 (12) 1 (25)
 Nervous system, n (%) 20 (42) 0 (0) 3 (75)
Laboratory test
 ESR, mm/h 87 (40–121) 109 (59–122) 71 (33–112)
 White blood cells, 103 cells/μL 9.5 (7.0–13) 9.5 (7.0–14) 7.7 (6.6–9.1)
 Neutrophils, 103 cells/μL 6.2 (4.4–8.4) 5.4 (4.6–7.0) 6.1 (2.6–8.4)
 Lymphocytes, 103 cells/μL 1.5 (1.0–1.8) 1.4 (1.1–1.8) 1.1 (0.8–1.6)
 Monocytes, cells/μL 414 (308–623) 460 (343–565) 444 (235–737)
 Eosinophils, cells/μL 223 (116–814) 119 (67–192) 109 (7–755)
 Haemoglobin, g/dL 11 (9.6–13) 11 (10–12) 12 (11–13)
 Platelets, 104 cells/μL 34 (25–41) 34 (29–42) 28 (18–36)
 CRP, mg/dL 3.9 (0.7–8) 4.8 (2.4–6.5) 0.8 (0.3–5.2)
 IgG, mg/dL 1648 (1120 − 1905) 1437 (1140–1690) 1325 (1124–2223)
 MPO-ANCA-/PR3-ANCA-positive/ANCA-negative, n 34/8/6 1/0/25 0/0/4
 MPO-ANCA titre, U/mL 41 (13–171), n = 34 28, n = 1
 PR3-ANCA titre, U/mL 14 (10–39), n = 8
 Rheumatoid factor positive, n (%) 37 (79) 2 (8) 1 (25)
 Rheumatoid factor, IU/mL 65 (32–141) 29 (16–42) 41, n = 1
  1. AAV ANCA-associated vasculitis, MPA microscopic polyangiitis, GPA granulomatosis with polyangiitis, EGPA eosinophilic granulomatosis with polyangiitis, LVV large-vessel vasculitis, GCA giant cell arteritis, TAK Takayasu arteritis, PAN polyarteritis nodosa, BVAS Birmingham vasculitis activity score, ESR erythrocyte sedimentation rate, CRP C-reactive protein, MPO myeloperoxidase, PR3 proteinase 3