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Table 2 Results of gene set enrichment analysis

From: Identification of neutrophil β2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses

  MAPP name Number changed Number measured Number on MAPP Permute P Adjusted P
AAV > HC IL-6 pathway 26 89 100 < 0.001 0.0022
IL-5 pathway 25 63 69 < 0.001 0.014
Integrin-mediated cell adhesion 24 79 99 < 0.001 0.030
Insulin signalling pathway 38 128 159 < 0.001 0.049
MAPK signalling pathway 36 129 162 0.001 0.071
EGFR1 pathway 38 148 177 < 0.001 0.093
Focal adhesion 34 132 187 < 0.001 0.13
MAPK cascade 10 22 29 0.001 0.057
B cell receptor pathway 36 146 158 0.001 0.23
Regulation of actin cytoskeleton 25 95 146 0.005 0.33
IL-3 pathway 24 93 101 0.008 0.39
Pentose phosphate pathway 4 7 7 0.011 0.31
Glycogen metabolism 10 31 36 0.011 0.59
Proteasome degradation 16 59 61 0.014 0.62
Cytochrome P450 9 28 71 0.016 0.65
IL-1 pathway 11 35 38 0.017 0.57
Eicosanoid synthesis 6 16 19 0.030 0.67
AAV < HC Ribosomal proteins 27 86 88 < 0.001 < 0.001
Homologous recombination 4 12 13 0.012 0.002
Inflammatory response pathway 5 21 33 0.029 0.071
Synthesis and degradation of ketone bodies 2 4 5 0.035 0.076
RV > HC Proteasome degradation 9 59 61 < 0.001 0.020
Prostaglandin synthesis regulation 4 20 31 0.003 0.099
Apoptosis 6 76 82 0.019 0.80
Nucleotide GPCRs 2 10 105 0.037 0.54
Electron transport chain 6 87 105 0.042 0.93
RV < HC Inflammatory response pathway 2 21 33 0.041 0.84
PAN > HC Oxidative stress 3 18 28 0.010 0.31
Nucleotide GPCRs 2 10 11 0.016 0.44
Statin pathway 2 12 20 0.038 0.64
Eicosanoid synthesis 2 16 19 0.048 0.85
PAN < HC Wnt signalling and pluripotency 4 64 97 0.015 0.83
TAK > HC Apoptosis 4 76 82 0.008 0.63
Hypertrophy model 2 14 20 0.014 0.23
GPCRDB class A Rhodopsin-like 4 115 262 0.049 0.96
TAK < HC S1P signalling 2 20 25 0.038 0.67
  1. MAPP microarray pathway profiler, AAV ANCA-associated vasculitis, RV rheumatoid vasculitis, PAN polyarteritis nodosa, TAK Takayasu arteritis, HC healthy controls