Table 2 Comparison of the most abundantly expressed proteins in the inflammatory foci of CLE and DM skin lesions
Numbers of proteins | CLE/HC | DM/HC | CLE/DM |
|---|---|---|---|
Interleukin-16 (IL-16) (x fold) | 12 | 1 | 12 |
IFN regulated and associated proteins, high in both LE and DM (x fold) | |||
IFIT1 | 71 | 57 | 1.2 |
IFIT3 | 70 | 46 | 1.3 |
DDX58 | 48 | 33 | 1.5 |
ISG15 | 48 | 30 | 1.6 |
OAS2 | 36 | 21 | 1.7 |
MX1 | 31 | 16 | 2 |
MX2 | 29 | 14 | 2 |
STAT1 | 29 | 16 | 1.9 |
OAS3 | 28 | 33 | 0.83 |
EIF2AK2 | 23 | 15 | 1.5 |
IFI44L | 18 | 18 | 1 |
IFIT2 | 13 | 11 | 1.2 |
DDX21 | 6 | 6.5 | 1 |
IFI16 | 6 | 4.5 | 1.1 |
ADAR | 7.3 | 5 | 1.4 |
IFN-regulated and associated proteins, high in LE but low in DM (x fold) | |||
MNDA | 31 | Low* | 31 |
PTPN6 | 24 | Low* | 24 |
DDX60 | 18 | Low* | 18 |
STAT2 | 14 | Low* | 3.8 |
ZC3HAV1 | 14 | Low* | 7 |
OASL | 14 | Low* | 14 |
IFI44 | 10 | Low* | 1.6 |
IFIT5 | 8 | Low* | 2 |
OAS1 | 8 | Low* | 8 |
Antigen processing and transport (x fold) | |||
TAP1 | 18.5 | 10 | 1.9 |
TAP2 | 24 | 19 | 1.3 |
TAPBP | 5.4 | 1.1 | |
Aminoacyl-tRNA synthases and other enzymes (x fold) | |||
WARS | 90 | 55 | 1.6 |
TARS | 13 | 10 | 1.3 |
TYMP | 9.4 | 9 | 1 |
ACLY | 28 | 9 | 3 |
GOT1 | 8 | 8 | 1 |