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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways

Fig. 3

Fargesin enhances M2 macrophage polarization and mounts anti-inflammatory cytokines in OA synovium and serum. (a-f) Immunostaining and quantitative analysis of cells positive for F4/80 (a, b), iNOS (c, d), and CD206 (e, f) in CIOA mice treated with vehicle or fargesin three and six weeks after intra-articular injection collagenase. Scale bar: 50 μm. Higher magnification is shown on the right top. Scale bar: 100 μm. (g-i) ELISA results for IL-1β, IL-6, and IL-10 levels in CIOA mouse serum treated with vehicle or fargesin three and six weeks after intra-articular injection collagenase (n = 4). AC, articular cartilage; MM, medial meniscus

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Arthritis Research & Therapy

ISSN: 1478-6362

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