Fig. 3From: Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathwaysFargesin enhances M2 macrophage polarization and mounts anti-inflammatory cytokines in OA synovium and serum. (a-f) Immunostaining and quantitative analysis of cells positive for F4/80 (a, b), iNOS (c, d), and CD206 (e, f) in CIOA mice treated with vehicle or fargesin three and six weeks after intra-articular injection collagenase. Scale bar: 50 μm. Higher magnification is shown on the right top. Scale bar: 100 μm. (g-i) ELISA results for IL-1β, IL-6, and IL-10 levels in CIOA mouse serum treated with vehicle or fargesin three and six weeks after intra-articular injection collagenase (n = 4). AC, articular cartilage; MM, medial meniscusBack to article page