Fig. 1

APS cohort in the Peking Union Medical College Hospital database. A total of 244 patients with persistent positive of aPL were followed up, including those with primary APS, secondary APS, and non-criteria APS. After excluding 17 patients with incomplete data, 77 males, 21 patients with only extra-clinical manifestations, 9 female secondary APS patients, and 15 female primary APS lost to follow-up, a total of 105 female primary APS patients with outcome were enrolled in the cohort. Our study included 39 patients with ItAPS and pregnancy history, 44 patients with IoAPS, and 9 patients with tAPS+oAPS. Patients who lacked a history of pregnancy were excluded