Table 1 Characteristics of the index pregnancies complicated by severe preeclampsia in 40 women with APS
Patient’s characteristics | N = 40 (%) |
|---|---|
Previous thrombotic events | 14 (35.0) |
Previous obstetric manifestations of APS | 9 (22.5) |
Known APS | 12 (30.0) |
Associated SLEa | 11 (27.5) |
Primiparous | 21 (52.5) |
Mean age at index pregnancy ± SD | 30.5 ± 4.6 |
Antibody profile | |
IgG/IgM anti-cardiolipin antibodies | 34 (85.0) |
IgG/IgM anti-β2GPI antibodies | 25 (62.5) |
LAC | 33 (82.5) |
Triple-positive aPL antibody tests | 21 (52.5) |
Treatment during index pregnancy, before onset of preeclampsia | |
Only LDA | 4 (10.0) |
Only LMWH | 4 (10.0) |
LDA + LMWH | 15 (37.5) |
Hydroxychloroquine | 7 (17.5) |
Glucocorticoids | 8 (20.0) |
Immunosuppressants | 3 (7.5) |
None | 17 (42.5) |
Features of severe preeclampsia | |
Term at onset, weeks of gestation (median, IQR) | 25.5 (23–29) |
Foetal outcome | |
IUFD | 11 (27.5) |
Neonatal death | 15 (37.5) |
Survival at 28 days after birth | 14 (35.0) |
Gestational age at birth of surviving children (n = 14) | 31 (27–33) |
Preterm delivery (< 37 weeks) among surviving children (n = 14) | 14 (100.0) |
IUGR among surviving children | 2 (14.3) |
Associated maternal complications | |
HELLP syndrome | 18 (45.0) |
Eclampsia | 6 (15.0) |
Placental abruption | 3 (7.5) |
Catastrophic APS | 3 (7.5) |