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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma

Fig. 1

Fli1 heterozygous deficiency suppresses the activity of ALDH in CD103CD11b dermal DCs in BLM-treated mice. Wild-type (WT) and Fli1+/ mice were treated with bleomycin (BLM) for a week. a Representative flow cytometry plots of ALDH staining in CD11c+ cells from the dermis of BLM-treated WT and Fli1+/ mice are shown (left panels). The result in the presence of the ALDH inhibitor diethylaminobenzaldehyde (DEAB) is shown as control. The proportions of CD11c+ cells positive for ALDH are summarized in a right graph (n = 6–7 per group). b Representative flow cytometry plots of CD11b and CD103 staining in ALDH-producing CD11c+ cells from the dermis of BLM-treated WT and Fli1+/ mice are shown (n = 6–7 per group). c Mean fluorescence intensity (MFI) of ALDH was examined in CD11bCD103 DCs isolated from the dermis. Each graph indicates mean ± SEM of the indicated parameters. * P < 0.05; ** P < 0.01

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