Table 2 Comparison of patient backgrounds of full-term birth and preterm birth
Full-term birth | Preterm birth | p value | |
|---|---|---|---|
Number of patients | 56 | 27 | |
Gestational age at delivery, weeks | 38.0 (37.0–39.0) | 34.0 (32.0–36.0) | < 0.001 |
Birth weight, g | 2892 (2610–3115) | 2154 (1568–2400) | < 0.001 |
Age, years | 32 (30–36) | 34 (31–36) | 0.249 |
SLE duration, years | 7.5 (3.3–11.8) | 9.0 (5.0–16.0) | 0.056 |
Lupus nephritis, n (%) | 8 (14.3) | 14 (51.9) | < 0.001 |
APS, n (%) | 21 (37.5) | 12 (44.4) | 0.634 |
SLEDAI, score | 0 (0–4) | 1 (0–4) | 0.225 |
SLEDAI ≥ 4, n (%) | 3 (5.4) | 5 (18.5) | 0.103 |
Preeclampsia, n (%) | 3 (5.4) | 5 (18.5) | 0.106 |
Comorbidity | |||
Diabetes mellitus, n (%) | 5 (8.9) | 6 (22.2) | 0.163 |
Hypertension, n (%) | 3 (5.4) | 5 (18.5) | 0.106 |
Past use of steroid pulse therapy, n (%) | 7 (12.5) | 11 (40.7) | 0.009 |
Past use of IVCY, n (%) | 6 (10.7) | 5 (18.5) | 0.326 |
Prednisolone dose, mg/day | 9.0 (3.1–11.0) | 10.0 (7.0–12.0) | 0.181 |
Azathioprine, n (%) | 14 (25.0) | 3 (11.1) | 0.245 |
Tacrolimus, n (%) | 25 (44.6) | 15 (55.6) | 0.482 |
HCQ, n (%) | 5 (8.9) | 4 (14.8) | 0.463 |
Serum C3 level, mg/dL | 87.5 (75.0–96.3) | 77.5 (68.2–84.8) | 0.027 |
Positive Anti-ds-DNA Ab, n (%) | 35 (62.5) | 20 (74.1) | 0.333 |
Anti-dsDNA Ab, IU/ml | 5.9 (3.0–8.4) | 3.0 (1.8–7.4) | 0.082 |
Positive anti-Ro/SS-A Ab, n (%) | 19 (33.9) | 10 (37.0) | 0.810 |
Positive anti-RNP Ab, n (%) | 19 (33.9) | 9 (33.3) | 1.000 |
Positive anti-Sm Ab, n (%) | 3 (5.4) | 3 (11.1) | 0.385 |