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Fig. 10 | Arthritis Research & Therapy

Fig. 10

From: Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats

Fig. 10

Immunohistochemistry assay for a ADAMTS-4, aggrecan, and MMP-13 in the nucleus pulposus in different groups. bd Immunohistological analysis showed that the protein expression of aggrecan in the OVX+PLF+Dmab group was higher than that in the OVX+PLF group. MMP-13 and ADAMTS-4-positive staining in the nucleus pulpous were weaker in the OVX+PLF+Dmab group compared to the OVX+PLF group. Note: *P < 0.05, **P < 0.01; scale bars = 50 μm as indicated

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