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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats

Fig. 4

Changes in microarchitecture and porosity of L5/6 caudal endplate quantified by μCT analysis. Representative coronal images and parameters of caudal endplate in all groups (a). More cavities in OVX and OVX+PLF rats (red arrow) indicate osteochondral endplate remodeling. be Compared with the Sham group, a markedly lower number of closed pores (Po.N(cl)), higher open porosity (Po(op)), and total pore volume (Po.V(tot)) occurred in the OVX and OVX+PLF groups. The OVX+PLF+Dmab group showed a significantly higher number of closed pores, and lower open porosity (Po(op)) and total volume of pore space (Po.V(tot)) compared to the OVX+PLF group. Note: *P < 0.05, **P < 0.01; scale bars = 2 mm and 1 mm as indicated

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