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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats

Fig. 6

Histological illustration of the L5–L6 segments of the lumbar spine in different groups. a Safranin O and fast green staining of L5–L6. b Safranin-O green staining of cartilage endplate. Green hollow pentagram indicates cartilage endplate cells, and green solid quadrilateral indicates new bony tissue. c The degenerative changes in the nucleus pulposus visualized with safranin-O green staining. A white triangle indicates notochordal cells, thin white arrow indicates chondrocyte-like cells, and large white arrow indicates mucoid degeneration. d Safranin O and fast green staining of annulus fibrosus (blue asterisk indicates regular annulus fibrosus, blue pound sign indicates cleft/crack, thin blue arrow indicates chondrocyte-like cells, and large blue arrow indicates mucoid degeneration in the annulus fibrosus). Note:, vertebral epiphysis; , cartilage endplate; , vertebral physis; , bony tissue; scale bars = 500 μm and 100 μm as indicated

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