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Fig. 9 | Arthritis Research & Therapy

Fig. 9

From: Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats

Fig. 9

Tartrate acid phosphatase (TRAP) staining of L5/6. The osteoclasts were obtained by counting the number of TRAP-positive cells (N. Trap+). a A few TRAP-positive cells were distributed on the surface of the trabeculae of the subchondral bone and were rarely detected in the endplates of Sham and OVX+PLF+Dmab groups. However, TRAP-positive cells were significantly more frequent in the subchondral bone and the endplate of the OVX+PLF group, suggesting reduced osteoclast activity after Dmab treatment. b TRAP staining of CrEP (purple; yellow arrows). c TRAP staining of CaEP (purple; blue arrows). df Quantitative analysis of TRAP-positive cells for IVD, CrEP, and CaEP. Note: *P < 0.05, **P < 0.01. IVD intervertebral disc, CrEP cranial endplate, CaEP caudal endplate; scale bars = 500 μm and 50 μm as indicated

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