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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Circulating mature granzyme B+ T cells distinguish Crohn’s disease-associated axial spondyloarthritis from axial spondyloarthritis and Crohn’s disease

Fig. 3

T cells in patients with CD-axSpA are skewed towards a cytotoxic effector memory profile. Singlet, viable lymphocytes gated on CD3+ TCRβ+ cells followed by CD4+ and CD8+ per group were evaluated for the percent of (a) CD45RA+ CCR7+ naïve cells versus (b) CD45RA− CCR7− effector memory T cells (TEM) and (c) GZMB+ TEM within the CD4+ population. d Of the CD8+ T cells, the percent naïve CD45RA+ CCR7+ cells are shown. The percent of PD-1+ cells in the (e) CD4+ and (f) CD8+ populations are shown. Data are shown as individual subjects (dots) with bars as the mean ± SEM. *, P ≤ 0.05 as determined by Mann-Whitney for non-parametric data and t-test for parametric data as determined by D’Augostino and Shapiro-Wilk tests

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Arthritis Research & Therapy

ISSN: 1478-6362

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