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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: The heterogeneous human memory CCR6+ T helper-17 populations differ in T-bet and cytokine expression but all activate synovial fibroblasts in an IFNγ-independent manner

Fig. 4

IL-17A plays a role in SF activation, but not in induction of a pro-inflammatory loop. Th17, Th17.1, DP, and DN CCR6+ memTh cells were sorted from healthy controls and cultured for 3 days with anti-CD3 and anti-CD28 stimulation, with the addition of 100 μg/ml secukinumab or an isotype control. ELISA was used to measure SF-derived mediators (A), T-cell derived cytokines (B), and PGE2 (C) in the culture supernatant on day 3. Data represent mean ± SEM from n = 6 subjects, pooled from 2 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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