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Table 2 Difference of CD4 T subsets between HC and SLE, and between active and remission group

From: Therapeutic potential of targeting Tfr/Tfh cell balance by low-dose-IL-2 in active SLE: a post hoc analysis from a double-blind RCT study

Variables

HC

(n=23)

SLE

P,

HC VS. Active

P, remission VS. active

Active (n=60)

(Before therapy)

Remission (n=59)

(After therapy)

Proportion (percentage in lymphocyte, %)

 Treg

1.22 (1, 1.47)

0.95 (0.65, 1.53)

1.6 (0.97, 2.49)

0.087

0.001

 CXCR5+PD-1lowTreg

0.09 (0.04, 0.14)

0.06 (0.03, 0.1)

0.13 (0.06, 0.25)

0.033

<0.001

 CXCR5+PD-1highTreg

0.01 (0.007, 0.013)

0.003 (0.002, 0.008)

0.02 (0.009, 0.052)

<0.001

<0.001

 Tfh

0.28 (0.17, 0.43)

0.39 (0.24, 0.56)

0.19 (0.09, 0.37)

0.081

0.002

 Tfh1

0.61 (0.38, 0.99)

0.2 (0.08, 0.36)

0.17 (0.09, 0.28)

<0.001

0.42

 Tfh2

1.06 (0.58, 1.5)

0.42 (0.21, 0.6)

0.36 (0.19, 0.68)

<0.001

0.367

 Tfh17

0.45 (0.15, 0.65)

0.47 (0.27, 0.87)

0.44 (0.2, 0.83)

0.345

0.851

Absolute number (cells/μl)

 Treg

25.51 (19.98, 30.78)

11.94 (6, 20.81)

20.51 (9.17, 29.06)

0.035

0.014

 CXCR5+PD-1lowTreg

2.98 (1.71, 3.1)

0.67 (0.24, 1.21)

1.33 (0.8, 3.54)

0.037

0.005

 CXCR5+PD-1highTreg

0.39 (0.28, 0.43)

0.04 (0.02, 0.11)

0.24 (0.11, 0.72)

0.006

<0.001

 Tfh

7.29 (4.34, 8.92)

4.6 (2.58, 10.28)

2.84 (0.81, 6.04)

0.625

0.008

 Tfh1

14.26 (12.37, 18.22)

2.11 (0.95, 5.47)

1.92 (0.68, 4.28)

0.002

0.427

 Tfh2

19.31 (14.66, 24.22)

4.43 (2.11, 11.2)

4.04 (1.73, 11.88)

0.002

0.751

 Tfh17

8.82 (7.25, 12.22)

5.39 (2.33, 14.38)

4.67 (2.47, 10.36)

0.642

0.664

Ratios

 Treg/Tfh

3.69 (3.04, 8.49)

2.49 (1.89, 4.5)

8.93 (4.04, 18.29)

0.002

<0.001

 CXCR5+PD-1lowTreg/Tfh

0.3 (0.21, 0.57)

0.16 (0.08, 0.31)

0.61 (0.4, 1.32)

0.002

<0.001

 CXCR5+PD-1highTreg/Tfh

0.06 (0.04, 0.08)

0.01 (0, 0.02)

0.1 (0.06, 0.2)

<0.001

<0.001

 Treg/Tfh17

3.87 (2.27, 5.71)

2.29 (1.23, 4.21)

3.89 (2.01, 6.62)

0.047

<0.001

 CXCR5+PD-1lowTreg/Tfh17

0.25 (0.17, 0.34)

0.11 (0.05, 0.22)

0.28 (0.18, 0.52)

0.002

<0.001

 CXCR5+PD-1highTreg/Tfh17

0.04 (0.03, 0.06)

0.01 (0, 0.02)

0.04 (0.02, 0.08)

<0.001

<0.001

  1. SLE systemic lupus erythematosus, HC healthy controls. Data are median (IQR)s