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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Plasma metabolomic profiling in patients with rheumatoid arthritis identifies biochemical features predictive of quantitative disease activity

Fig. 2

Plasma metabolites differentiating between higher and lower disease activity groups in RA. A total of 2 and 31 metabolites were found to be significantly increased in higher (DAS28-CRP > 3.2, n = 52) and lower (DAS28-CRP ≤ 3.2, n = 76) disease activity groups, respectively. Each point corresponds to a metabolite (686 total). Differentially abundant metabolites were found using a mixed-effects logistic regression model on the discovery cohort (128 samples), for which age and sex were adjusted. Metabolites with a P-value < 0.05 (based upon the corresponding coefficient of the regression model) were considered as significantly different between the groups. P-values and fold changes for all metabolites are listed in Additional file 6. Metabolites in bold have been previously described in the literature for their associations with RA

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