Independent variables | Radiographic OA progression ≥0.5mm at follow-up: n (%) | |||
---|---|---|---|---|
Yes (n = 58) | No (n = 440) | Unadjusted odds ratio | p-value | |
Clinical factors | ||||
Sex (female) | 29 (50%) | 253 (58%) | 0.74 (0.43, 1.28) | 0.28 |
Aged >60 years | 34 (59%) | 238 (54%) | 1.20 (0.69, 2.10) | 0.52 |
Obesitya | 30 (52%) | 225 (51%) | 1.02 (0.59, 1.77) | 0.93 |
High blood pressure | 17 (29%) | 146 (33%) | 0.84 (0.46, 1.52) | 0.56 |
Heberden nodes | 17 (29%) | 130 (30%) | 0.99 (0.54, 1.80) | 0.97 |
Manual occupation | 11 (19%) | 63 (14%) | 1.40 (0.69, 2.85) | 0.35 |
Knee trauma or surgery history | 24 (41%) | 182 (41%) | 1.00 (0.57, 1.75) | 1.00 |
No glucosamine/chondroitin | 46 (79%) | 323 (73%) | 1.39 (0.71, 2.71) | 0.34 |
Use of NSAIDs | 21 (36%) | 119 (27%) | 1.53 (0.86, 2.72) | 0.14 |
Use of statins | 16 (28%) | 115 (26%) | 1.08 (0.58, 1.99) | 0.81 |
Inadequate physical activity | 50 (86%) | 330 (75%) | 2.08 (0.96, 4.53) | 0.06 |
High baseline pain (WOMAC pain >10) | 8 (14%) | 104 (24%) | 0.52 (0.24, 1.13) | 0.09 |
Poor physical function (WOMAC PF>33) | 9 (16%) | 100 (23%) | 0.62 (0.30, 1.32) | 0.21 |
Structural disease severity | ||||
Disease severity (K&L grade ≥ 2) | 39 (67%) | 186 (42%) | 2.80 (1.57, 5.01) | <0.001 |
Minimal joint space width (<3.13mm) | 27 (47%) | 89 (20%) | 3.44 (1.95, 6.05) | <0.001 |
Varus alignment (≤178°) | 19 (33%) | 54 (12%) | 3.45 (1.86, 6.39) | <0.001 |