Skip to main content

Table 2 Univariate analyses: number (%) with radiographic OA progression, p values for the association between independent variables and radiographic OA progression (JSN ≥ 0.5mm) using Pearson χ2

From: Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study

Independent variables

Radiographic OA progression

≥0.5mm at follow-up: n (%)

  
 

Yes (n = 58)

No (n = 440)

Unadjusted odds ratio

p-value

Clinical factors

 Sex (female)

29 (50%)

253 (58%)

0.74 (0.43, 1.28)

0.28

 Aged >60 years

34 (59%)

238 (54%)

1.20 (0.69, 2.10)

0.52

 Obesitya

30 (52%)

225 (51%)

1.02 (0.59, 1.77)

0.93

 High blood pressure

17 (29%)

146 (33%)

0.84 (0.46, 1.52)

0.56

 Heberden nodes

17 (29%)

130 (30%)

0.99 (0.54, 1.80)

0.97

 Manual occupation

11 (19%)

63 (14%)

1.40 (0.69, 2.85)

0.35

 Knee trauma or surgery history

24 (41%)

182 (41%)

1.00 (0.57, 1.75)

1.00

 No glucosamine/chondroitin

46 (79%)

323 (73%)

1.39 (0.71, 2.71)

0.34

 Use of NSAIDs

21 (36%)

119 (27%)

1.53 (0.86, 2.72)

0.14

 Use of statins

16 (28%)

115 (26%)

1.08 (0.58, 1.99)

0.81

 Inadequate physical activity

50 (86%)

330 (75%)

2.08 (0.96, 4.53)

0.06

 High baseline pain (WOMAC pain >10)

8 (14%)

104 (24%)

0.52 (0.24, 1.13)

0.09

 Poor physical function (WOMAC PF>33)

9 (16%)

100 (23%)

0.62 (0.30, 1.32)

0.21

Structural disease severity

 Disease severity (K&L grade ≥ 2)

39 (67%)

186 (42%)

2.80 (1.57, 5.01)

<0.001

 Minimal joint space width (<3.13mm)

27 (47%)

89 (20%)

3.44 (1.95, 6.05)

<0.001

 Varus alignment (≤178°)

19 (33%)

54 (12%)

3.45 (1.86, 6.39)

<0.001

  1. aObesity defined as body mass index ≥ 30kg/m2 and/or high waist circumference (>102cm for men, >88cm for women)
  2. NSAIDs non-steroidal anti-inflammatory drugs, WOMAC Western Ontario and McMaster Universities OA index, PF Physical Function subscale, K&L Kellgren and Lawrence