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Table 2 Univariate analyses: number (%) with radiographic OA progression, p values for the association between independent variables and radiographic OA progression (JSN ≥ 0.5mm) using Pearson χ2

From: Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study

Independent variables Radiographic OA progression
≥0.5mm at follow-up: n (%)
  
  Yes (n = 58) No (n = 440) Unadjusted odds ratio p-value
Clinical factors
 Sex (female) 29 (50%) 253 (58%) 0.74 (0.43, 1.28) 0.28
 Aged >60 years 34 (59%) 238 (54%) 1.20 (0.69, 2.10) 0.52
 Obesitya 30 (52%) 225 (51%) 1.02 (0.59, 1.77) 0.93
 High blood pressure 17 (29%) 146 (33%) 0.84 (0.46, 1.52) 0.56
 Heberden nodes 17 (29%) 130 (30%) 0.99 (0.54, 1.80) 0.97
 Manual occupation 11 (19%) 63 (14%) 1.40 (0.69, 2.85) 0.35
 Knee trauma or surgery history 24 (41%) 182 (41%) 1.00 (0.57, 1.75) 1.00
 No glucosamine/chondroitin 46 (79%) 323 (73%) 1.39 (0.71, 2.71) 0.34
 Use of NSAIDs 21 (36%) 119 (27%) 1.53 (0.86, 2.72) 0.14
 Use of statins 16 (28%) 115 (26%) 1.08 (0.58, 1.99) 0.81
 Inadequate physical activity 50 (86%) 330 (75%) 2.08 (0.96, 4.53) 0.06
 High baseline pain (WOMAC pain >10) 8 (14%) 104 (24%) 0.52 (0.24, 1.13) 0.09
 Poor physical function (WOMAC PF>33) 9 (16%) 100 (23%) 0.62 (0.30, 1.32) 0.21
Structural disease severity
 Disease severity (K&L grade ≥ 2) 39 (67%) 186 (42%) 2.80 (1.57, 5.01) <0.001
 Minimal joint space width (<3.13mm) 27 (47%) 89 (20%) 3.44 (1.95, 6.05) <0.001
 Varus alignment (≤178°) 19 (33%) 54 (12%) 3.45 (1.86, 6.39) <0.001
  1. aObesity defined as body mass index ≥ 30kg/m2 and/or high waist circumference (>102cm for men, >88cm for women)
  2. NSAIDs non-steroidal anti-inflammatory drugs, WOMAC Western Ontario and McMaster Universities OA index, PF Physical Function subscale, K&L Kellgren and Lawrence