Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review

Mulder, Michelle L. M.; van Hal, Tamara W.; Wenink, Mark H.; Koenen, Hans J. P. M.; van den Hoogen, Frank H. J.; de Jong, Elke M. G. J.; van den Reek, Juul M. P. A.; Vriezekolk, Johanna E.

doi:10.1186/s13075-021-02545-4

Table 3 Best evidence synthesis of genetic markers

From: Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review

Category	Marker	Good/fair quality studies	Poor quality studies	Evidence
HLA	Haplotype B08:01-C07		1x positive association [97]	Limited evidence of positive association
	Haplotype B08-C07-MICA*00801	1x positive association [98]		Moderate evidence of positive association
	Haplotype B18-C07		1x positive association [99]	Limited evidence of positive association
	Haplotype B27-C01		2x positive association [97, 99]	Moderate evidence of positive association
	Haplotype B27-C02		3x positive association [97, 99, 100]	Moderate evidence of positive association
	Haplotype B27-C02-MICA*00701/026	1x positive association [98]		Moderate evidence of positive association
	Haplotype B35-C04-MICA*0201/020	1x negative association [98]		Moderate evidence of negative association
	Haplotype B37-C06		1x negative association [97]	Limited evidence of negative association
	Haplotype B38-C12		3x positive association [97, 99, 100]	Moderate evidence of positive association
	Haplotype B39:01-C12		2x positive association [97, 100]	Moderate evidence of positive association
	Haplotype B57-C06		2x negative association [97, 99]	Moderate evidence of negative association
	Haplotype B57-C06-MICA*017		1x negative association [99]	Limited evidence of negative association
	HLA-A*03		1x mixed results [101]	Conflicting evidence
	HLA-B*08		2x positive association [97, 99] 3x no association [100, 102, 103]	Conflicting evidence
	HLA-B*13		1x mixed results [101] 2x no association [102, 104]	Conflicting evidence
	HLA-B*18		1x positive association [97] 1x no association [100]	Conflicting evidence
	HLA-B*27		6x positive association [97, 99, 100, 103,104,105] 1x no association [102]	Moderate evidence of positive association
	HLA-B*37		1x negative association [97] 1x no association [102]	Conflicting evidence
	HLA-B*38		3x positive association [97, 99, 100] 1x no association [104] 1x mixed results [101]	Conflicting evidence
	HLA-B*39		1x positive association [100] 1x mixed results [97]	Conflicting evidence
	HLA-B*40		1x negative association [97]	Limited evidence of negative association
	HLA-B*44		1x negative association [97]	Limited evidence of negative association
	HLA-B*57		1x negative association [99] 3x no association [100, 102, 104]	Moderate evidence of no association
	HLA-B*70		1x mixed results [101]	Conflicting evidence
	HLA-B amino acid position 45 Glu		1x positive association [106] 2x no association [102, 103]	Conflicting evidence
	HLA-B amino acid position 95 Leu		1x positive association [102]	Limited evidence of positive association
	HLA-B amino acid position 97 Arg		1x mixed results [103] 1x no association [102]	Conflicting evidence
	HLA-C*01		1x positive association [99] 3x no association [97, 100, 102]	Moderate evidence of no association
	HLA-C*02		2x positive association [97, 99] 2x no association [100, 102]	Conflicting evidence
	HLA-C*06	1x negative association [107]	7x negative association [97, 99, 102,103,104,105, 108] 2x no association [100, 109] 1x mixed results [101]	Moderate evidence of negative association
	HLA-C*07		1x positive association [99] 2x no association [100, 102]	Conflicting evidence
	HLA-C*08		1x negative association [105]	Limited evidence of negative association
	HLA-C*12		1x positive association [100] 2x no association [99]	Conflicting evidence
	HLA-C amino acid position 305 Ala		1x positive association [102]	Limited evidence of positive association
	HLA-C rs10484554		1x positive association [110]	Limited evidence of positive association
	HLA-C rs12191877		1x negative association [111]	Limited evidence of negative association
	HLA-DQB1*02		1x mixed results [101] 1x no association [102]	Conflicting evidence
	HLA-DRB1*03		2x no association [101, 102]	Moderate evidence of no association
	HLA-DR*04		1x positive association [101]	Limited evidence of positive association
	HLA-DR*07		1x negative association [105]	Limited evidence of negative association
	HLA-DR*11		1x mixed results [101]	Conflicting evidence
Non-HLA	ADAMTS9-MAG1 deletion		1x positive association [112]	Limited evidence of positive association
	CCR2 rs1799864	1x positive association [113]		Limited evidence of positive association
	IL1RN rs397211		2x no association [111, 114]	Moderate evidence of no association
	IL12B rs2082412		2x negative association [111, 114]	Moderate evidence of negative association
	IL12B rs3212227	1x no association [115]	1x no association [109]	Moderate evidence of no association
	IL12B rs6887695	1x no association [115]	1x no association [109]	Moderate evidence of no association
	IL13 rs1800925	1x positive association [116]	1x positive association [117]	Moderate evidence of positive association
	IL13 rs20541		2x positive association [114, 117] 1x not associated [111]	Conflicting evidence
	IL13 rs848	1x positive association [116]		Moderate evidence of positive association
	IL17E rs79877597		1x positive association [118]	Limited evidence of positive association
	IL23A rs2066807		2x not associated [111, 114]	Moderate evidence of no association
	IL23R rs11209026	1x no association [115]	1x no association [109]	Moderate evidence of no association
	IL23R rs2201841		1x negative association [111] 1x not associated [114]	Conflicting evidence
	KIR2DS1 pos/C2 neg		1x positive association [119]	Limited evidence of positive association
	LOC100505817 rs4891505		1x positive association [120]	Limited evidence of positive association
	MICA*00701/026	1x positive association [98]		Moderate evidence of positive association
	MICA*00801	1x positive association [98]		Moderate evidence of positive association
	MICA*016	1x negative association [98]		Moderate evidence of negative association
	NFKBIA rs7152376	1x positive association [107]		Moderate evidence of positive association
	PTPN22 rs2476601		1x positive association [121]	Limited evidence of positive association
	TNFa-238		2x not associated [109, 122]	Moderate evidence of no association
	TNFa-308		2x not associated [109, 122]	Moderate evidence of no association
	TNFa-857		1x positive association [109]	Limited evidence of positive association
	TNFacd haplotype a6c1d3		1x positive association [123]	Limited evidence of positive association
	TNFAIP3 rs610604		2x not associated [111, 114]	Moderate evidence of no association
	TNIP rs17728338		2x not associated [111, 114]	Moderate evidence of no association
	TRAF3IP2 rs240993		1x not associated [114]	Limited evidence of no association
	TRAF3IP2 rs458017		1x not associated [110]	Limited evidence of no association
	TSC1 rs1076160		2x not associated [111, 114]	Moderate evidence of no association
	ZNF816A		1x negative association [114]	Limited evidence of negative association

A positive association is defined as a higher risk of PsA when the marker is present/increased/higher. A negative association is defined as a lower risk of PsA when the marker is present/increased/higher.
ADAMTS a disintegrin and metalloproteinase with thrombospondin motifs, Arg arginine, CCR C-C motif receptor, Glu glutamic acid, HLA human leukocyte antigen, IL interleukin, IL1RN IL-1 receptor antagonist, IL23R IL-23 receptor, KIR killer-cell immunoglobulin-like receptor, MAGI membrane-associated guanylate kinase, MICA MHC class I polypeptide-related sequence A, PTPN22 protein tyrosine phosphatase non-receptor type 22, TNF tumor necrosis factor, TNFAIP TNF alpha-induced protein, TNIP TNFAIP3-interacting protein, TRAF TNF receptor-associated factor, TRAF3IP TRAF3-interacting protein, TSC1 tuberous sclerosis 1, ZNF zinc finger protein

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ISSN: 1478-6362

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