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Table 1 Characteristics, laboratory data, and treatments of SLE patients with and without LN

From: Identification of monoclonal antibodies against human renal glomerular endothelial cells in lupus nephritis that induce endothelial interferon-alpha production

 

LN patients (N = 12)

SLE patients without LN (N = 12)

Female: male

10:2

11:1

Age in years

17.34 (11–27)

17.93 (12–27.8)

Laboratory data

 ANA (+)

12 (100%)

12 (100%)

 Anti-dsDNA Ab (+)

12 (100%)

12 (100%)

 Anti-dsDNA Ab level (IU/ml)*

790.04 ± 257.39

508.25 ± 277.07

 DRVVT and/or IgG/IgM anticardiolipin Ab (+)

4 (33.3%)

3 (25%)

 WBC count (× 103/ml)

6292.20 ± 4097.73

5632.50 ± 2435.47

 Hemoglobin (g/dl)**

9.63 ± 1.92

11.9 ± 1.36

 Platelet count (× 103/ml)

210.00 ± 99.10

220.17 ± 96.94

 C3 (mg/ml)**

40.67 ± 18.45

76.16 ± 18.79

 C4 (mg/ml)**

7.41 ± 3.78

13.52 ± 5.35

Treatments (ever used)

 Corticosteroid

12 (100%)

12 (100%)

 MP pulse therapy**

11 (91.7%)

3 (25%)

 CTX pulse therapy**

9 (75%)

1 ( 8.33%)

 HCQ

12 (100%)

12 (100%)

 AZA

5 (41.7%)

6 (50%)

 CsA

7 (58.3%)

6 (50%)

 MTX

3 (25%)

2 (16.7%)

 MMF

5 (41.7%)

4 (33.3%)

  1. ANA antinuclear antibodies, Ab antibodies, DRVVT dilute Russell viper venom time, C complement, MP methylprednisolone, CTX cyclophosphamide, HCQ hydroxychloroquine, AZA azathioprine, CsA cyclosporine A, MTX methotrexate, MMF mycophenolate mofetil
  2. *Significant difference (p < 0.05) between LN patients and SLE patients without LN
  3. **Significant difference (p < 0.001) between LN patients and SLE patients without LN